ISSN: 1859 - 2872
Study on the predictive value of the Neutrophil-to-Lymphocyte Ratio for 14-day mortality in patients with septic shock
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Abstract
Objective: Evaluate the association between the Neutrophil-to-Lymphocyte Ratio (NLR) and 14-day mortality in patients with septic shock. Subject and method: A prospective cross-sectional study was conducted at the Intensive Care Center of 108 Military Central Hospital from April 2023 to January 2024. The study included patients aged 18 and above with septic shock. NLR was measured at different time points: at the diagnosis of septic shock, on days 1, 3, 5, and 7 post-diagnosis. The study aimed to evaluate the differences and variations in NLR between two groups: surviving and deceased patients. Additionally, the study compared the predictive value of NLR for mortality with the SOFA and APACHE II scores in septic shock patients. Result: A total of 97 patients were included in the study. The average NLR in the deceased group was higher than in the surviving group at T3 and T5 (p<0.05). NLR at T3 (AUC = 0.71; p<0.01) and T5 (AUC = 0.69, p<0.05) had a moderate predictive value for mortality but lower than the SOFA and APACHE II scores. NLR in both patient groups at T0 and T1 remained relatively constant; the NLR ratio at T3 for both groups increased compared to T0 and T1, but the deceased group showed a steeper increase. The NLR of the deceased group gradually decreased at T5 and T7, while this ratio in the surviving group remained nearly unchanged. The average value of the NLR at various study time points in the deceased group tended to be higher than in the surviving group, with significance at T3 and T5 (p<0.01). Conclusion: The NLR measured on days 3 and 5 is a valuable predictor of 14-day mortality in patients with septic shock.
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References
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