Căn nguyên vi sinh vật gây nhiễm khuẩn đường hô hấp dưới và tính kháng kháng sinh của các chủng phân lập được tại Bệnh viện Đại học Phenikaa

Abstract

Objective: To evaluate the level of antibiotic resistance of bacterial strains causing lower respiratory tract diseases isolated at Phenikaa University Hospital. Subject and method: Cross-sectional, prospective study on 399 specimens, including 218 sputum samples and 181 bronchoalveolar lavage (BAL) samples collected from patients with symptoms of lower respiratory tract infections, from January to October 2025. Result: 229 positive samples. The rate of Pseudomonas aeruginosa was 11.1%, Klebsiella pneumoniae 10%, Streptococcus mitis 15.6%, Streptococcus pneumoniae 3.1%, Aspergillus 2.8%. The positive ESBL rate of Klebsiella pneumoniae was 20%, of Escherichia coli was 67%. Pseudomonas aeruginosa had the highest resistance rate to Cefazolin (96.3%), Carbapenem 55-63%. Klebsiella pneumoniae was resistant to Ampicillin 92.9%, the lowest resistance rate to Imipenem (8%). Streptococcus sp. had the highest resistance rate to Clindamycin (76.1%), Tetracycline 72.2%; and was sensitive to Vancomycin (100%), Linezolid (100%), Chloramphenicol, Tigecyclin (93.2%). Conclusion: Pathogenic Gram-negative bacteria isolated from lower respiratory tract specimens have high resistance rates to antibiotics used for treatment. Some antibiotics are highly sensitive to Gram-negative bacteria such as Imipenem, Meropenem, and highly sensitive to Gram-positive cocci such as Vancomycin, Linezolid, Tigecyclin.