MRSA sepsis complicated by splenic abscess and nephrotic syndrome in a young diabetic patient: A case report

  • Nguyen Van Tung 108 Central Military Hospital
  • Vu Viet Sang 108 Central Military Hospital
  • Nguyen Dinh Luan 108 Central Military Hospital

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Tóm tắt

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of invasive infections, but splenic abscess and nephrotic syndrome are rare complications, especially in young diabetics. Case Presentation: We describe a 27-year-old Vietnamese woman with type 1 diabetes who developed fever, scalp and thigh abscesses, edema, MRSA sepsis, nephrotic-range proteinuria (8.9 g/24h), hypoalbuminemia, pleural effusions, and a splenic abscess. CT also showed an incidental adrenal mass. Cultures from blood and abscesses grew MRSA. She improved with IV vancomycin, meropenem, amikacin, and supportive care (albumin, insulin, antihypertensives). Conclusion: This case demonstrates a rare and complex form of MRSA sepsis with nephrotic syndrome and splenic abscess, illustrating the need for prompt recognition and multidisciplinary treatment.

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Các tài liệu tham khảo

1. Liu C, Bayer A, Cosgrove SE et al (2011) Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 52(3): 18-55. doi:10.1093/cid/ciq146.
2. PMC (2024) Immune responses to methicillin-resistant Staphylococcus aureus: review. MDPI.
3. Arslan F, van Nieuwkoop C, Hofhuis A et al (2015) Splenic abscesses: a rare complication of Staphylococcus aureus bacteremia. Springerplus 4: 208. doi: 10.1186/s40064-015-0981-3.
4. Moghimi Z, Sadeghian E, Notash AY et al (2023) Splenic abscess due to non-operative management of splenic injury: A case report. Journal of Medical Case Reports 17: 305.
5. StatPearls (2025) Splenic abscess. NCBI Bookshelf.
6. Koyama A, Kobayashi M, Yamagata K et al (1995) Glomerulonephritis associated with MRSA infection: A possible role of bacterial superantigen. Am J Kidney Dis 25(3): 449-453 doi:10.1016/0272-6386(95)90125-6
7. Hashimoto K, Itoh K, Yoshida K et al (2013) A case of IgA-dominant glomerulonephritis associated with MRSA infection: Significance of superantigens. Clin Nephrol 80(5): 392-396. doi:10.5414/CN107896
8. Wiley (2024) Staphylococcus aureus subcapsular splenic abscess and associated empyema after tocilizumab. Clinical Case Reports.
9. Couser WG (1991) Glomerulonephritis: the role of immune complexes in glomerular injury. Am J Kidney Dis 17(4): 471-480.doi:10.1016/S0272 6386(12)80497-2.
10. Gross JL, de Azevedo MJ, Silveiro SP, Canani LH, Caramori ML & Zelmanovitz T (2005) Diabetic nephropathy: Diagnosis, prevention, and treatment. Diabetes Care 28(1): 164-176. https://doi.org/10.2337/diacare.28.1.164
11. Alicic RZ, Rooney MT & Tuttle KR (2017) Diabetic kidney disease: Challenges, progress, and possibilities. Clinical Journal of the American Society of Nephrology 12(12): 2032-2045. https://doi.org/10.2215/CJN.11491116.
12. Fioretto P & Mauer M (2007) Diabetic nephropathy: Diabetic nephropathy-challenges in pathologic classification. Nature Clinical Practice Nephrology 3(8): 443-454. https://doi.org/10.1038/ncpneph0530
13. KDIGO (2020) KDIGO 2020 clinical practice guideline for diabetes management in chronic kidney disease. Kidney International Supplements 10(4): 1-115. https://doi.org/10.1016/j.kisu.2020.11.00.