Current status of implementation of centralized antibiotic compounding for neonates at the National Hospital of Obstetrics and Gynecology

  • Lê Thị Lan Anh Bệnh viện Phụ sản Trung ương
  • Nguyễn Linh Phương Trường Đại học Dược Hà Nội
  • Đỗ Phạm Minh Châu Trường Đại học Dược Hà Nội
  • Nguyễn Huy Tuấn Bệnh viện Phụ sản Trung ương
  • Lê Minh Trác Bệnh viện Phụ sản Trung ương
  • Nguyễn Đình An Bệnh viện Phụ sản Trung ương
  • Nguyễn Thành Hải Trường Đại học Dược Hà Nội
  • Lê Bá Hải Trường Đại học Dược Hà Nội

Main Article Content

Keywords

Centralized compounding, aseptic technique, IV antibiotics, neonates, pharmacists

Abstract

Objective: This study aimed to evaluate the implementation of a sterile antibiotic compounding model for neonates at the National Hospital of Obstetrics and Gynecology. Subject and method: A mixed-method study, combining retrospective data review with prospective observation. The compounding room was assessed in accordance with the standards outlined in Chapter <797> of the United States Pharmacopeia (USP 797, 2024): “Pharmaceutical Compounding - Sterile Preparations”. Adherence of compounding personnel to standard operating procedures (SOPs) was evaluated through 16 randomly conducted observations. Result: The compounding facility complied with USP <797> (2024) standards. Air quality met ISO requirements; however, humidity frequently exceeded 60%, and Staphylococcus aureus and Staphylococcus epidermidis were occasionally detected. Most procedures followed SOPs, though compliance was incomplete in certain steps, such as mask wearing (87%), head covering (81%), cleaning of biological safety cabinets (94%), disinfection of packages (94%) and disinfection before handling medications (89%). Conclusion: The compounding room met key international standards for infrastructure and aseptic conditions. Ongoing improvement of environmental control, staff training, and supervision is essential to enhance performance and ensure the safety of compounded sterile preparations for neonates.

Article Details

References

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Published
Dec 30, 2025
DOI: https://doi.org/10.52389/ydls.v20i8.2895
Issue
Volume 20-No 8/2025
Section
Articles
How to Cite
AnhL. T. L., PhươngN. L., Châu Đỗ P. M., TuấnN. H., TrácL. M., AnN. Đình, HảiN. T., & HảiL. B. (2025). Current status of implementation of centralized antibiotic compounding for neonates at the National Hospital of Obstetrics and Gynecology. Tạp Chí Y Dược lâm sàng 108, 20(8). https://doi.org/10.52389/ydls.v20i8.2895