ISSN: 1859 - 2872
A case report of meigs’ syndrome caused by ovarian fibrothecoma with high levels of CA-125
Main Article Content
Keywords
Abstract
Meigs syndrome is a rare gynecological disease that is difficult to diagnose preoperatively, characterized by a triad of benign ovarian tumors, ascites, and pleural effusion. Ovarian malignancies should be highly suspected in women with a pelvic mass, ascites, pleural effusion, and an elevated carbohydrate antigen 125 (CA-125) level. A 39-year-old woman with a 2-week history of abdominal distension and pelvic pain was admitted to the National Hospital of Obstetrics and Gynecology. Physical examination revealed a solid mass measuring 10x15cm with an undetermined origin. Ultrasound showed a mixed echo mass consisting of 2 large lobes, with no distinguishable border with the right ovary, severe ascites, and chest X-ray with right pleural effusion. The CA-125 concentration was 137 U/mL. The patient underwent laparoscopic excision of the ovarian mass, and the final pathology was consistent with an ovarian fibrothecoma. At the 2-month postoperative follow-up, ascites and pleural effusion had resolved and did not recur, and CA-125 levels returned to normal.
Article Details
References
2. Yuan L, Cui L, Wang J, Gong L (2024) A Case Report of Meigs’ Syndrome Caused by Ovarian Fibrothecoma with High Levels of CA125. Int J Womens Health 16: 519-525. doi:10.2147/IJWH.S450833
3. Chen J, Gu H, zhang Y et al (2022) MRI-based nomogram for differentiation of ovarian fibrothecoma and broad ligament myoma. Sci Rep 12: 8122. doi:10.1038/s41598-022-12218-0
4. Zhang Z, Wu Y, Gao J (2015) CT diagnosis in the thecoma-fibroma group of the ovarian stromal tumors. Cell Biochem Biophys 71(2): 937-943. doi:10.1007/s12013-014-0288-7
5. Hou YY, Peng L, Zhou M (2021) Meigs syndrome with pleural effusion as initial manifestation: A case report. World J Clin Cases 9(21): 5972-5979. doi:10.12998/wjcc.v9.i21.5972
6. Nguyen P, Yazdanpanah O, Schumaker B, Meigs’ Versus Pseudo-Meigs’ Syndrome: A Case of Pleural Effusion, Ascites, and Ovarian Mass. Cureus. 12(8): 9704. doi:10.7759/cureus.9704
7. Wu XJ, Xia HB, Jia BL et al (2021) Meigs’ syndrome caused by granulosa cell tumor accompanied with intrathoracic lesions: A case report. World J Clin Cases. 9(18): 4734-4740. doi: 10.12998/wjcc.v9.i18.4734
8. Abramov Y, Anteby SO, Fasouliotis SJ, Barak V (2001) Markedly elevated levels of vascular endothelial growth factor, fibroblast growth factor, and interleukin 6 in Meigs syndrome. Am J Obstet Gynecol. 184(3): 354-355. doi: 10.1067/mob.2001.110028
9. Miyawaki E, Naito T, Kasamatsu Y (2021) Pseudo-Meigs’s syndrome. BMJ Case Rep 14(2): 241337. doi: 10.1136/bcr-2020-241337
10. Shen Y, Liang Y, Cheng X, Lu W, Xie X, Wan X (2018) Ovarian fibroma/fibrothecoma with elevated serum CA125 level. Medicine (Baltimore). 97(34): 11926. doi:10.1097/MD.0000000000011926
11. Mohammed SA, Kumar A, Cue L (2024) Meigs Syndrome. In: StatPearls. StatPearls Publishing; 2024. Accessed September 14, 2024. http://www.ncbi.nlm.nih.gov/books/NBK559322/
12. Miyoshi A, Miyatake T, Hara T et al (2015) Etiology of Ascites and Pleural Effusion Associated with Ovarian Tumors: Literature Review and Case Reports of Three Ovarian Tumors Presenting with Massive Ascites, but without Peritoneal Dissemination. Case Rep Obstet Gynecol: 414019. doi:10.1155/2015/414019
Article Sidebar
