Kết quả sử dụng nicardipin tĩnh mạch trên bệnh nhân tăng huyết áp sau mổ lấy thai tại Khoa Hồi sức cấp cứu Bệnh viện Phụ sản Trung ương

Abstract

Objective: To describe the intravenous nicardipine regimen and the outcomes on blood pressure control in postpartum women with hypertension after cesarean section. Subject and method: A retrospective descriptive study was conducted in postpartum women with hypertension after cesarean section who received intravenous nicardipine at the Intensive Care Unit, National Hospital of Obstetrics and Gynecology, from January 1 to December 31, 2024. Data were collected from medical records. Result: A total of 165 women were included. The median initial dose of IV nicardipine was 2.0mg/h, with a maximum of 8mg/h. During nicardipine infusion, 78.2% of patients received additional antihypertensive medications, primarily methyldopa. A total of 56.4% of patients achieved target blood pressure before discontinuation of nicardipine, whereas all patients (100%) achieved target blood pressure before discharge. Rebound hypertension occurred in 22.4% of cases after nicardipine discontinuation. Adverse events included systolic blood pressure < 110mmHg in 18.2% and heart rate > 100 beats/min in 67.9% of patients. Conclusion: Intravenous nicardipine regimens and subsequent transition therapy are highly effective in managing postpartum blood pressure. Close monitoring of blood pressure and heart rate, along with dose titration of nicardipine and optimization of combination and transition regimens, remain essential to maximize treatment efficacy and minimize adverse events.