ISSN: 1859 - 2872
Clinical features and the role of patch test in delayed drug hypersensitivity reactions: Introduction of two cases
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Abstract
Delayed drug allergy is a type IV hypersensitivity reaction that usually occurs several hours to several weeks after exposure to the drug. Objective: To present the clinical characteristics of delayed drug allergy and the diagnostic value of patch testing in two cases diagnosed and treated at Center of Demato - Venereology, Allergy, 108 Military Central Hospital. Case 1 is DRESS syndrome caused by carbamazepine with symptoms of fever, generalized erythema, severe liver and kidney damage. Case 2 is fixed pigmentary erythema caused by metronidazole with recurrent erythematous patches in the same location. Both cases were accurately identified as the allergen by patch testing with positive results for the suspected drug (carbamazepine in case 1 and Metronidazole in case 2). Conclusion: Patch testing plays an important role in diagnosing the cause of drug allergy, contributing to recommendations for safe drug use for patients.
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References
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