Nghiên cứu khả năng kích thích liền xương của vật liệu ZK60 khi được phủ hydroxyapatite (HA) trên thực nghiệm

Abstract

Objective: To evaluate the effects of hydroxyapatite (HA)-coated ZK60 materials on bone healing in experimental animals. Subject and method: 84 healthy white rabbits were randomly divided into three groups: Group 1 (n = 28): Implanted with HA-coated ZK60 magnesium alloy bone plates and screws. Group 2 (n = 28): Implanted with uncoated ZK60 bone plates and screws. Group 3 (n = 28): Implanted with titanium bone plates and screws. All rabbits underwent femoral bone defect surgery, where bone plates were implanted into the femur. Digital X-ray imaging was performed before surgery and at 3, 7, 30, 60, 90, and 180 days post-operation to assess bone shadow formation. Histological analysis was also conducted at these time points to evaluate the bone healing process. Result: On X-ray images, from 30^th day, the HA-coated ZK60 group showed a higher rate of bone shadow presence and more uniform bone density compared to the uncoated ZK60 and titanium groups. Histologically, at 30^th day, only the HA-coated ZK60 group exhibited the formation of soft callus. At 60^th day, all samples in this group showed mature (hard) callus formation, whereas the other two groups only began to show soft callus at day 60. Conclusion: HA-coated ZK60 material demonstrated the highest bone-healing stimulation potential among all experimental groups.