Ultrasound biomicroscopic characteristics of the anterior segment in patients with primary congenital glaucoma

  • Đào Thị Mai Anh Trường Đại học Y Hà nội
  • Nguyễn Ngọc Sơn Bệnh viện Mắt Trung ương
  • Nguyễn Thị Hoa Bệnh viện TWQĐ 108
  • Bùi Thị Vân Anh Bệnh viện Mắt Trung ương

Main Article Content

Keywords

Primary congenital glaucoma, ultrasound biomicroscopic

Abstract

Objective: To evaluate ultrasound biomicroscopic features of anterior segment in eyes with primary congenital glaucoma. Subject and method: This was a cross-sectional study, 16 patients diagnosed with primary congenital glaucoma included in the study had anterior segment ultrasound performed under anesthesia using VuMax Bua machine with 50MHz frequency probe. Result: 16 cases (9 males and 7 females) with 24 eyes with primary congenital glaucoma (PCG) were confirmed, mean age was 5.8 ± 3.1 years. 16 eyes (66.7%) had abnormal angle structure, 41.7% had iris anterior insertion and ciliary body attachment to the iris was found in 12.5%. PCG eyes had greater corneal diameter, anterior chamber depth and zonular length than normal eyes (12.7 ± 1.23 mm, 3.9 ± 0.4 mm, 1.5 ± 0.4 mm with p<0.001, p<0.001 and p<0.05, respectively). The mean iris thickness in study group was 0.27 ± 0.07mm, smaller than normal group, p<0.05. Conclusion: Ultrasound biomicroscopic is a useful method to detect structural changes of anterior segment in patients with PCG. This tool can help confirm diagnosis as well as contribute to understand pathogenesis.

Article Details

References

1. Kaur K, Gurnani B (2024) Primary Congenital Glaucoma. In: StatPearls. StatPearls Publishing; 2024.
2. Kaur K, Mandal AK, Chakrabarti S (2011) Primary Congenital Glaucoma and the Involvement of CYP1B1. Middle East Afr J Ophthalmol 18(1): 7-16.
3. Sampaolesi R, Sampaolesi JR, Jorge Z (2009) The glaucomas: Volume I-Pediatric glaucomas. The Glaucomas: Volume I-Pediatric Glaucomas. 1-486. 10.1007/978-3-540-69146-4.
4. Amini H, Fakhraie G, Abolmaali S, Amini N, Daneshvar R (2012) Central Corneal Thickness in Iranian Congenital Glaucoma Patients. Middle East Afr J Ophthalmol 19(2): 194-198.
5. Mastropasqua L, Carpineto P, Ciancaglini M, Nubile M, Doronzo E (2002) In Vivo Confocal Microscopy in Primary Congenital Glaucoma With Megalocornea. Journal of Glaucoma 11(2): 83.
6. Hussein MAW, Paysse EA, Bell NP et al (2004) Corneal thickness in children. American Journal of Ophthalmology 138(5): 744-748.
7. Abdeen W, Esmael AF, Gawdat G, El-Fayoumi D (2022) Anterior chamber angle features in primary congenital glaucoma infants using hand-held anterior segment-oct. Eye 36(6): 1238-1245.
8. Azuara-Blanco A, Spaeth GL, Araujo SV et al (1997) Ultrasound biomicroscopy in infantile glaucoma. Ophthalmology 104(7): 1116-1119.
9. Janssens R, van Rijn LJ, Eggink CA, Jansonius NM, Janssen SF (2022) Ultrasound biomicroscopy of the anterior segment in patients with primary congenital glaucoma: A review of the literature. Acta Ophthalmologica 100(6): 605-613.
10. Gupta V, Jha R, Srinivasan G, Dada T, Sihota R (2007) Ultrasound biomicroscopic characteristics of the anterior segment in primary congenital glaucoma. J AAPOS 11(6): 546-550.
11. deLuise VP, Anderson DR (1983) Primary infantile glaucoma (congenital glaucoma). Survey of Ophthalmology 28(1): 1-19.
12. Hussein TR, Shalaby SM, Elbakary MA, Elseht RM, Gad RE (2014) Ultrasound biomicroscopy as a diagnostic tool in infants with primary congenital glaucoma. Clin Ophthalmol 8: 1725-1730.
13. Shi Y, Han Y, Xin C et al (2020) Disease-related and age-related changes of anterior chamber angle structures in patients with primary congenital glaucoma: An in vivo high-frequency ultrasound biomicroscopy-based study. PLoS One 15(1): 0227602.
14. Tandon A, Watson C, Ayyala R (2017) Ultrasound biomicroscopy measurement of Schlemm’s canal in pediatric patients with and without glaucoma. J AAPOS 21(3): 234-237.