ISSN: 1859 - 2872
Correlation between HbA1c levels and dyslipidemia in type 2 diabetes mellitus patients at Xuyen A General Hospital
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Abstract
Objective: This study aimed to evaluate the correlation between glycated hemoglobin (HbA1c) levels and blood lipid profiles in patients with type 2 diabetes mellitus (T2DM) at Xuyen A General Hospital. Subject and method: A cross-sectional analytical study was conducted on 222 patients with T2DM from October 2024 to February 2025. Laboratory data including fasting glucose, HbA1c, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and non-HDL-cholesterol (non-HDL-C) were collected. Spearman correlation coefficients were used to assess associations between HbA1c and lipid components. Result: The median HbA1c level was 7.4% (interquartile range: 6.5 – 9.2%). A statistically significant positive correlation was observed between HbA1c and total cholesterol (ρ=0.71; p<0.001), triglycerides (ρ=0.53; p<0.001), LDL-C (ρ=0.61; p<0.001), and non-HDL-C (ρ = 0.71; p<0.001). No significant correlation was found between HbA1c and HDL-C (ρ=0.03; p=0.626). Conclusion: HbA1c levels are significantly associated with various lipid parameters in patients with T2DM, particularly with atherogenic lipids. These findings suggest that monitoring HbA1c may provide additional value in assessing cardiovascular risk through its correlation with lipid abnormalities.
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References
2. International Diabetes Federation (2021) IDF Diabetes Atlas, 10th edn. Brussels: IDF. PMID: 35914061.
3. Bộ Y tế (2022) Báo cáo điều tra yếu tố nguy cơ bệnh không lây nhiễm STEPS 2021. Nhà xuất bản Y học, Hà Nội.
4. Mooradian AD (2009) Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 5(3): 150-159.doi:10.1038/ncpendmet1066.
5. Miller M, Stone NJ, Ballantyne C et al (2011) Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association. Circulation 123(20): 2292-2333. doi: 10.1161/CIR.0b013e3182160726.
6. WHO/IDF (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Geneva: World Health Organization.
7. Luo B, Xu W, Ye D et al (2024) Association Between Glycated Hemoglobin and the Lipid Profile at the Central Yunnan Plateau: A Retrospective Study. Diabetes Metab Syndr Obes 17:2975-2981. doi:10.2147/DMSO.S469368.
8. Yadav N, Singh S, Gupta S, Mishra S, & Singh K (2019) Correlation between glycemic control and dyslipidemia in Type 2 Diabetes Mellitus patient. International Journal of Basic & Clinical Pharmacology 8(6): 1387–1392.
9. American Diabetes Association (2022) 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022. Diabetes Care 45(Suppl 1): 17-38. doi:10.2337/dc22-S002.
10. Bộ Y tế (2014) Quyết định số 3879/QĐ-BYT ngày 30/9/2014 về Hướng dẫn chẩn đoán và điều trị bệnh Nội tiết - Chuyển hóa.
11. Bộ Y tế (2010) Quyết định số 3192/QĐ-BYT ngày 31/8/2010 về việc ban hành Hướng dẫn chẩn đoán và điều trị tăng huyết áp.
12. Nguyễn Văn Hoàn, Trần Minh Thái, Nguyễn Thị Hồng Vân (2021) Tương quan giữa HbA1c và lipid máu ở bệnh nhân đái tháo đường típ 2 tại Nghệ An. Nội tiết - Đái tháo đường & RLCH 16(1), tr. 33-40.
13. Artha IMJR, Bhargah A, Dharmawan NK et al (2019) High level of individual lipid profile and lipid ratio as a predictive marker of poor glycemic control in type-2 diabetes mellitus. Vascular Health and Risk Management: 149-157. doi: 10.2147/VHRM.S209830.
14. Begum A, Sultana R, Hossain MA et al (2019) Relationship between glycated hemoglobin level and lipid profile in type 2 diabetic patients. Bangladesh Med J 48(2): 35-39. doi: 10.3329/bccj.v7i1.40767.
15. Nguyễn Thị Hoa, Vũ Thị Hoài Thu & Phạm Thị Quyên (2022) Tỷ số TG/HDL C và một số chỉ số lipid huyết tương ở bệnh nhân đái tháo đường type 2 tại Bệnh viện Trường Đại học Y Dược Thái Nguyên. Tạp chí Y học Việt Nam, 519(Số chuyên đề tháng 10), tr. 80-88.
16. Zhu HT, Yu M, Hu H (2019) Factors associated with glycemic control in community-dwelling elderly individuals with type 2 diabetes mellitus in Zhejiang, China: A cross-sectional study. BMC Endocrine Disorders 19: 1-11. doi: 10.1186/s12902-01.
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