Results of embryo transfer on day 5 at A Thai Nguyen Hospital

  • Nguyễn Thị Hồng Trường Đại học Y Dược Thái Nguyên
  • Dương Thúy Mai Trường Đại học Y Dược Thái Nguyên
  • Sầm Thị Thùy Trường Đại học Y Dược Thái Nguyên
  • Hứa Minh Tuân Bệnh viện A Thái Nguyên
  • Hoàng Quốc Huy Trường Đại học Y Dược Thái Nguyên
  • Nguyễn Thị Kim Thu Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

Embryo transfer, blastocyst day 5, hCG positive

Abstract

Objective: To assess the outcomes of Day 5 embryo transfer in patients undergoing in vitro fertilization (IVF) at the Reproductive Support Department, A Thai Nguyen Hospital. Subject and method: Retrospective cross-sectional descriptive method of 376 infertility patients who underwent in vitro fertilization at the Reproductive Support Department - A Thai Nguyen Hospital from January 2024 to December 2024. Result: The average age of the wives was 31.55 ± 4.86 years, with 75% of the patients being under 35 years of age. The average duration of infertility was 4.37 ± 3.30 years, with the majority having infertility for less than 5 years. The rates of positive βhCG, clinical pregnancy, biochemical pregnancy, and miscarriage were 57.7%, 42%, 9.3% and 4.3%, respectively. There was no significant difference in the quality of grade 1 and 2 embryos between the two age groups (< 35 and ≥ 35 years). A statistically significant correlation was found between the wife’s age and clinical pregnancy status. No statistically significant difference in the clinical pregnancy rate was observed according to the causes of infertility. Conclusion: Among 376 cases of day-5 embryo transfer, the rates of positive β-hCG, clinical pregnancy, biochemical pregnancy, and miscarriage were 57.7%, 42%, 9.3%, and 4.3%, respectively. There was no significant difference in the quality of grade 1 and 2 embryos between the two age groups (< 35 and ≥ 35 years). The clinical pregnancy rate was higher in women under 35 years of age. Maternal age was one of the factors influencing the outcome of day-5 embryo transfer. No association was found between the causes of infertility and the outcome of day-5 embryo transfer.

Article Details

References

1. Cameron NJ, Bhattacharya S, McLernon DJ (2020) Cumulative live birth rates following blastocyst- versus cleavage-stage embryo transfer in the first complete cycle of IVF: A population-based retrospective cohort study. Hum Reprod. 35(10), tr. 2365-2374.
2. Park DS, Kim JW, Chang EM, Lee WS, Yoon TK, Lyu SW (2019) Strategies in the transfer of varying grades of vitrified-warmed blastocysts in women aged over 35 years: A propensity-matched analysis. J Obstet Gynaecol Res 45(4): 849-857.
3. Lanlin Cai Yang, Sufen Zhang, Shuoping Kong, Xiangyi Gu, Yifan Lu, Changfu Dai, Jing Gong, Fei Lu, Guangxiu Lin, Ge Equivalence Trial (2018) Single embryo transfer by Day 3 time-lapse selection versus Day 5 conventional morphological selection: a randomized, open-label, non-inferiority trial. Hum Reprod 33(5): 869-876.
4. Bế Thị Hoa, Nguyễn, Duy Ánh, Nguyễn, Thị Thu Hà, Nguyễn Thị Hồng (2024) Kết quả chuyển phôi đông lạnh ngày 5 trên bệnh nhân được nuôi cấy phôi bằng hệ thống Timelapse tại Bệnh viện Phụ sản Hà Nội. Tạp chí Phụ sản, 22(4), tr. 147-151.
5. Dương Đình Hiếu, Nguyễn Đình Tảo, Hoàng Quản Lâm, (2013) Bước đầu đánh giá mối tương quan về hình thái phôi nuôi cấy ngày 3 và phôi nuôi cấy ngày 5 tại Trung tâm Công nghệ phôi. Tạp chí Y học Việt Nam. Số đặc biệt tháng 10, tr. 198-206.
6. Fragouli E, Alfarawati S, Spath K, Wells D (2013) Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos. Molecular Human Reproduction. 20(2), tr. 117-126.
7. Glujovsky D, Quinteiro Retamar AM, Alvarez Sedo CR, Ciapponi A, Cornelisse S, Blake D (2022) Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology. Cochrane Database of Systematic Reviews(5).
8. Hatirnaz S, Pektas MK (2017) Day 3 embryo transfer versus day 5 blastocyst transfers: A prospective randomized controlled trial. Turk J Obstet Gynecol 14(2): 82-88.
9. Javier M, Gutiérrez Romero Pilar Reimundo, Tamara Rodríguez Pérez, Ernesto Veiga (2021) Single-embryo transfer: A key strategy to reduce the risk for multiple pregnancy in assisted human reproduction. 2(2), tr. 179-188.
10. Pilar Reimundo, Javier M Gutiérrez Romero, Tamara Rodríguez Pérez, Ernesto Veiga (2021) Single-embryo transfer: A key strategy to reduce the risk for multiple pregnancy in assisted human reproduction. 2(2), tr. 179-188.