Evaluating the prognostic value of urinary liver-type fatty acid-binding protein (L-FABP) in predicting mortality among patients with sepsis and septic shock

  • Lê Xuân Dương Bệnh viện Trung ương Quân đội 108

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Keywords

Urinary L-FABP, prognosis, mortality

Abstract

Objective: To evaluate the prognostic value of urinary liver-type fatty acid-binding protein (L-FABP) in predicting mortality among patients with sepsis and septic shock. Subject and method: A prospective descriptive study was conducted on 212 patients with sepsis and septic shock at Military Central Hospital 108 from January 2021 to August 2024. Urine specimens were collected at the time of hospital admission, and urinary L-FABP levels were semi-quantitatively measured. In multivariate analysis was performed to determine whether L-FABP is an independent predictor of 7-day mortality and in- hospitality mortality. Result: The urinary L-FABP concentration in the 7-day mortality group was 31.71 (11.39-176.87) µg/g-Cre, which was significantly  higher than in the survivor group [18.14 (5.09-35.45) µg/g-Cre]. Similarly, the concentration in the in-hospital mortality group 42.86 (17.71-73.63 µg/g-Cre was higher than that in the survival group [12.11 (3.70-21.00) µg/g-Cre]. At a cutoff point of urinary L-FABP = 19.34 µg/g Cre, the biomarker demonstrated a sensitivity of 70.2% and a specificity of 71.1% in predicting in-hospital mortality, with an area under the curve (AUC) of 0.80. Conclusion: The urinary L-FABP concentration is a valuable biomarker in predicting 7-day mortality and in-hospital mortality in patients with sepsis and septic shock.

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References

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Published
Jun 12, 2025
DOI: https://doi.org/10.52389/ydls.v20i4.2695
Issue
Volume 20-No 4/2025
Section
Articles
How to Cite
DươngL. X. (2025). Evaluating the prognostic value of urinary liver-type fatty acid-binding protein (L-FABP) in predicting mortality among patients with sepsis and septic shock. Tạp Chí Y Dược lâm sàng 108, 20(4). https://doi.org/10.52389/ydls.v20i4.2695