Nghiên cứu tác dụng giảm đau, chống viêm của cao chiết ethanol từ cây Pác lừ (ligustrum sinense lour.) Trên thực nghiệm

Abstract

Objective: This study aimed to assess the anti-nociceptive and anti-inflammatory properties of the ethanol extract from Ligustrum sinense Lour. (LE) in animal models. Subject and method: The analgesic effects were assessed using the hot-plate test and the acetic acid-induced writhing test. To examine the anti-inflammatory effects, we utilized two models: carrageenan-induced paw edema and the cotton pellet-induced granuloma test. Result: In the acetic acid writhing test, the presence of LE at a dose of 10.8 g/kg significantly reduced the number of writhes, indicating strong peripheral antinociceptive activity. At a dose of 1.8g/kg and 5.4g/kg, LE significantly reduced paw edema induced by carrageenan in rats, indicating its anti-inflammatory activity, particularly during the acute phase of inflammation. Additionally, LE at a dose of 3.6g/kg and 10.8g/kg effectively inhibited the formation of cotton pellet granulomas, suggesting it also has anti-inflammatory effects in the chronic phase. Conclusion: Overall, these findings demonstrate that the raw ethanol extract from Ligustrum sinense Lour. possesses potent anti-nociceptive and anti-inflammatory properties, making it a promising option for treating various inflammatory diseases.