ISSN: 1859 - 2872
Evaluating the practical value of the formula to calculate plasma LDL-C concentration
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Abstract
Objective: To evaluate the value of using Sampson's plasma LDL-C calculation formula on two concentration levels: Triglyceride < 4.5mmol/L and triglyceride ≥ 4.5mmol/L by comparing with LDL-C calculated by Friedewald formula and LDL-C measure directly at 2 corresponding concentration levels. Subject and method: A descriptive cross-sectional study on plasma LDL-C concentrations of 323 patients examined and treated at 108 Military Central Hospital from 11/2023 to 02/2024 (group 1 includes 98 samples with triglycerides <4.5mmol/L; group 2 includes 225 samples with triglycerides ≥ 4.5mmol/L). Result: There was a strong correlation between the Sampson and Friedewald formulas with the direct measurement method in both groups. The absolute difference D% between LDL-C calculated according to the two formulas Sampson, Friedewald and direct LDL-C: In the triglyceride group ≥ 4.5mmol/L, D% were 12.2% and 24.3%, respectively (p<0.05). In the remaining group, D% were: 1.36% and 4.61%, respectively (p<0.05). The Bland-Altman plot showed better agreement between the Sampson formula and directly measured LDL-C. Conclusion: For samples with triglyceride concentrations < 4.5mmol/L, both Sampson and Friedewald formulas for calculating LDL-C are suitable to replace the direct LDL-C measurement method. For samples with triglyceride concentrations ≥ 4.5mmol/L, Sampson formula is more accurate than Friedewald formula when used to calculate plasma LDL-C concentration, but is not suitable to replace the direct LDL-C measurement method as required by NCEP ATPIII.
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References
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