ISSN: 1859 - 2872
Application of indocyanine green (ICG) in endoscopic surgery for radi-cal treatment of gastric cancer: Research review and clinical application
Main Article Content
Keywords
Indocyanine green, gastric cancer, fluorescence, gastrectomy.
Abstract
In recent years, Indocyanine Green (ICG) has emerged as a valuable tool in laparoscopic radical gastrectomy, offering enhanced visualization of lymphatic structures and tissue perfusion. This review explores the applications of ICG in gastric cancer surgery, emphasizing its roles in sentinel lymph node mapping, lymphadenectomy, and intraoperative assessment of blood supply. Studies have demonstrated that ICG significantly improves lymph node retrieval rates and reduces the risk of anastomotic leakage. Despite certain limitations, its integration into minimally invasive surgery is gaining traction, highlighting the need for further research to refine its use and expand clinical adoption.
Article Details
References
1. ArmTan K, Kim YM (2024) Indocyanine green and near-infrared fluorescence-guided surgery for gastric cancer: a narrative review. J Minim Invasive Surg 27(4):185-197.
2. Dai ZY, Shen C, Mi XQ, Pu Q (2023) The primary application of indocyanine green fluorescence imaging in surgical oncology. Frontiers in Surgery 10: 1077492.
3. Kusano M, Kokudo N, Toi M, & Kaibori M (2016) ICG Fluorescence Imaging and Navigation Surgery, Texbook. Springer Japan. 2016.
4. Bertani C, Cassinotti E, Della Porta M, Pagani M, Boni L, Baldari L (2021) Indocyanine green-a potential to explore: narrative review. Annals of Laparoscopic and Endoscopic Surgery 7.
5. Calcara C, Cocciolillo S, Canavesio YM, Adamo V, Carenzi S, Lucci DI et al (2023) Endoscopic fluorescent lymphography for gastric cancer. World journal of gastrointestinal endoscopy 15(2): 32.
6. Chen QY, Xie JW, Zhong Q, Wang JB, Lin JX, Lu J, et al (2020) Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: A randomized clinical trial. JAMA surgery 155(4): 300-311.
7. Deng C, Zhang Z, Qi H, Guo Z, Liu Y, Xiao H et al (2022) Safety and efficacy of indocyanine green near-infrared fluorescent imaging-guided lymph nodes dissection during radical gastrectomy for gastric cancer: A systematic review and meta-analysis. Frontiers in oncology 12: 917541.
8. Zhong Q, Chen QY, Huang XB, Lin GT, Liu ZY, Chen JY et al (2021) Clinical implications of Indocyanine Green Fluorescence Imaging-Guided laparoscopic lymphadenectomy for patients with gastric cancer: A cohort study from two randomized, controlled trials using individual patient data. International Journal of Surgery 94: 106120.
9. Kim TH, Kong SH, Park JH, Son YG, Huh YJ, Suh YS, et al (2018) Assessment of the Completeness of Lymph Node Dissection Using Near-infrared Imaging with Indocyanine Green in Laparoscopic Gastrectomy for Gastric Cancer. J Gastric Cancer 18(2):161-171.
10. Huang Y, Pan M, Chen B (2021) A systematic review and meta-analysis of sentinel lymph node biopsy in gastric cancer, an optimization of imaging protocol for tracer mapping. World journal of surgery 45: 1126-1134.
2. Dai ZY, Shen C, Mi XQ, Pu Q (2023) The primary application of indocyanine green fluorescence imaging in surgical oncology. Frontiers in Surgery 10: 1077492.
3. Kusano M, Kokudo N, Toi M, & Kaibori M (2016) ICG Fluorescence Imaging and Navigation Surgery, Texbook. Springer Japan. 2016.
4. Bertani C, Cassinotti E, Della Porta M, Pagani M, Boni L, Baldari L (2021) Indocyanine green-a potential to explore: narrative review. Annals of Laparoscopic and Endoscopic Surgery 7.
5. Calcara C, Cocciolillo S, Canavesio YM, Adamo V, Carenzi S, Lucci DI et al (2023) Endoscopic fluorescent lymphography for gastric cancer. World journal of gastrointestinal endoscopy 15(2): 32.
6. Chen QY, Xie JW, Zhong Q, Wang JB, Lin JX, Lu J, et al (2020) Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: A randomized clinical trial. JAMA surgery 155(4): 300-311.
7. Deng C, Zhang Z, Qi H, Guo Z, Liu Y, Xiao H et al (2022) Safety and efficacy of indocyanine green near-infrared fluorescent imaging-guided lymph nodes dissection during radical gastrectomy for gastric cancer: A systematic review and meta-analysis. Frontiers in oncology 12: 917541.
8. Zhong Q, Chen QY, Huang XB, Lin GT, Liu ZY, Chen JY et al (2021) Clinical implications of Indocyanine Green Fluorescence Imaging-Guided laparoscopic lymphadenectomy for patients with gastric cancer: A cohort study from two randomized, controlled trials using individual patient data. International Journal of Surgery 94: 106120.
9. Kim TH, Kong SH, Park JH, Son YG, Huh YJ, Suh YS, et al (2018) Assessment of the Completeness of Lymph Node Dissection Using Near-infrared Imaging with Indocyanine Green in Laparoscopic Gastrectomy for Gastric Cancer. J Gastric Cancer 18(2):161-171.
10. Huang Y, Pan M, Chen B (2021) A systematic review and meta-analysis of sentinel lymph node biopsy in gastric cancer, an optimization of imaging protocol for tracer mapping. World journal of surgery 45: 1126-1134.
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Published
May 25, 2025
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Articles
How to Cite
TuấnN. A., & DưN. V. (2025). Application of indocyanine green (ICG) in endoscopic surgery for radi-cal treatment of gastric cancer: Research review and clinical application. Tạp Chí Y Dược lâm sàng 108, 20(3). https://doi.org/10.52389/ydls.v20i3.2681