ISSN: 1859 - 2872
Evaluate the value of urinary L-FABP in predicting the severity of acute kidney injury in patients with sepsis and septic shock
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Abstract
Objective: To evaluate the value of urinary L-FABP in predicting the severity of acute kidney injury (AKI) in patients with sepsis and septic shock. Subject and method: A prospective descriptive study conducted on 212 patients with sepsis and septic shock at 108 Military Central Hospital. Result: Urinary L-FABP concentration was significantly higher in patients with more advanced stages of acute kidney injury (AKI), with values of 44.26 (11.50-203.61) µg/gCre for stage 3, 32.56 (22.52-53.55) µg/gCre for stage 2, and 21.30 (16.71-53.87) µg/gCre for stage 1, respectively (p<0.001). At a urinary L-FABP cut-off point of 21.5 µg/gCre, it demonstrated a predictive value for severe AKI, exhibiting a sensitivity of 72.7% and specificity of 68.2%, with p<0.01 and AUC = 0.73. Conclusion: Urinary L-FABP had prognostic value in assessing the severity of acute kidney injury in patients with sepsis and septic shock. A urinary L-FABP cutoff of ≥ 21.5µg/g creatinine predicted severe acute kidney injury with a sensitivity of 72.7%, specificity of 68.2%, and an AUC of 0.73.
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