ISSN: 1859 - 2872
Comparison the result of basic coagulation test parameters on the ACL TOP 750 LAS and STAGO STA R Max automated coagulation analyzers
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Abstract
Objective: To evaluate the concordance of results for several basic coagulation tests between two automated coagulation analyzers, ACL TOP 750 LAS (Instrumentation Laboratory, USA) and STA R Max (Diagnostica Stago, France), in order to assess the feasibility of using a shared reference range in the laboratory. Subject and method: A total of 150 platelet-poor plasma samples from pediatric patients were analyzed for PT, INR, APTT, and Fibrinogen parameters. Result: PT%, INR, APTT (ratio), and Fibrinogen showed high concordance between the two analyzers, with a correlation coefficient (r²) > 0.8 and confidence intervals for the slope including 1. However, APTT (seconds) and Prothrombin Time (seconds) did not exhibit equivalence, with differences observed at a significant level. These discrepancies can be attributed to differences in measurement principles and activators used in the two systems. Conclusion: The study confirms that the two analyzers can share one reference range for PT%, INR, APTT (ratio), and Fibrinogen tests. However, PT (seconds) and APTT (seconds) are not equivalent, and separate reference ranges must be established for each analyzer when interpreting these parameters.
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References
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