ISSN: 1859 - 2872
Lactate/albumin ratio as a prognostic marker for mortality in septic shock patients
Main Article Content
Keywords
Abstract
Objective: This study aims to evaluate the prognostic value of the lactate/albumin ratio (LAR) in predicting 28-day mortality risk in patients with septic shock. Subject and method: A cross-sectional descriptive study was conducted on 163 patients with septic shock treated at 108 Military Central Hospital from January to December 2023. Data collected included age, gender, hematological and biochemical laboratory results, APACHE II and SOFA scores, and lactate/albumin ratio. Data analysis was performed using Epi-info version 7 and MedCalc_18.2.1. Result: The mean age of patients was 68.5 ± 16.9 years, with a 28-day mortality rate of 44.8%. The mortality group had higher lactate levels and lactate/albumin ratio compared to the survival group (p<0.05). ROC analysis showed that the AUC of LAR in predicting 28-day mortality was 0.61 (p=0.012), with a cut-off point of 0.11, sensitivity of 66%, and specificity of 56%. Conclusion: The lactate/albumin ratio may be a useful tool for predicting mortality risk in patients with septic shock.
Article Details
References
2. Lee SG, Song J, Park DW et al (2021) Prognostic value of lactate levels and lactate clearance in sepsis and septic shock with initial hyperlactatemia: A retrospective cohort study according to the Sepsis-3 definitions. Medicine (Baltimore) 100(7): 24835.
3. Cao Y, Su Y, Guo C, He L et al (2023) Albumin level is associated with short-term and long-term outcomes in sepsis patients admitted in the ICU: A large public database retrospective research. Clin Epidemiol 15: 263-273.
4. Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315(8): 801-810.
5. Bou Chebl R, Geha M, Assaf M et al (2021) The prognostic value of the lactate/albumin ratio for predicting mortality in septic patients presenting to the emergency department: A prospective study. Ann Med 53(1): 2268-2277.
6. Gharipour A, Razavi R, Gharipour M et al (2020) Lactate/albumin ratio: An early prognostic marker in critically ill patients. Am J Emerg Med 38(10): 2088-2095.
7. Trzeciak S, Dellinger RP, Chansky ME et al (2007) Serum lactate as a predictor of mortality in patients with infection. Intensive Care Med 33(6): 970-977.
8. Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348(2): 138-150.
9. Bakker J, Nijsten MWN, Jansen TC (2013) Clinical use of lactate monitoring in critically ill patients. Ann Intensive Care 3(1): 12.
10. Vincent JL, Dubois MJ, Navickis RJ et al (2003) Hypoalbuminemia in acute illness: Is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials. Ann Surg 237(3): 319-334.
Article Sidebar
