ISSN: 1859 - 2872
Adjusting vancomycin dose according to therapeutic drug monitoring in intermittent hemodialysis patients at Thanh Nhan hosptal
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Abstract
Objective: To analyze the results of implementing vancomycin dose adjustment according to the therapeutic drug monitoring (TDM) protocol and the factors related to vancomycin concentration in intermittent hemodialysis patients (IHD). Subject and method: In an interventional prospective study on 42 intermittent hemodialysis patients using vancomycin, data were collected daily through clinical practices of clinical pharmacists, doctors and nurses at the Thanh Nhan Hospital from July 2023 to July 2024. Vancomycin was administered after each dialysis session, and the dose was adjusted based on pre-dialysis drug concentrations to achieve a target Ctrough of 15-20mg/L. Result: The percentage of patients achieving the target concentration in the first measurement was 54.5% in the ESRD group and 0% in the non-ESRD group. In both groups, 59.5% of patients achieved the target concentration at least once. No factors were identified as related to pre-dialysis vancomycin concentrations in ESRD patients. Conclusion: The rate of achieving the target vancomycin concentration was higher in the ESRD group compared to the non-ESRD group undergoing intermittent hemodialysis. Further optimization of the initial dose regimen and therapeutic drug monitoring are needed to achieve the vancomycin target concentration early.
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