The value of serum phosphate level in predicting acute kidney injury in patients with septic shock

  • Pham Dang Hai 108 Military Central Hospital
  • Nguyen Thi Thuy Duong Lao Cai Obstetrics and Children's Hospital

Main Article Content

Keywords

Serum phosphate level, septic shock, acute kidney injury, prognosis

Abstract

Objective: This study aimed to determine the association between serum phosphate level and acute kidney injury (AKI) in patients with septic shock. Subject and method: A cross-sectional study was conducted on 94 patients with septic shock treated at the Intensive Care Unit of 108 Military Central Hospital from January to October 2023. Patients were classified based on the development of AKI according to AKIN criteria. Serum phosphate levels were measured within the first 24 hours, and clinical data were collected for analysis. Result: Among the 94 patients, 68 (72.3%) developed AKI. Serum phosphate levels in the AKI group (1.58 mmol/L) were significantly higher compared to the non-AKI group (0.95 mmol/L), with p<0.001. Serum phosphate level predicted AKI with an area under the ROC curve (AUC) of 0.78, a cutoff value of 1.07 mmol/L, sensitivity of 70.6%, and specificity of 76.9% (p<0.001). Conclusion: Serum phosphate level is associated with the developmentof acute kidney injury in patients with septic shock.

Article Details

References

1. Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315: 801-810. doi: 10.1001/jama.2016.0287.
2. Zarbock A, Nadim MK, Pickkers P et al (2023) Sepsis-associated acute kidney injury: Consensus report of the 28th acute disease quality initiative workgroup. Nat Rev Nephrol 19: 401-417.
3. Wong SK (2022) A review of current evidence on the relationship between phosphate metabolism and metabolic syndrome. Nutrients 14: 4525. doi: 10.3390/nu14214525.
4. Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8): 801-810.
5. Mehta RL, Kellum JA, Shah SV et al (2007) Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care 11: 31.
6. Thongprayoon C, Cheungpasitporn W, Mao MA, et al (2018) Admission hyperphosphatemia increases the risk of acute kidney injury in hospitalized patients. J Nephrol 31(2): 241-247.
7. Moon H, Chin HJ, Na KY et al (2019) Hyperphosphatemia and risks of acute kidney injury, end-stage renal disease, and mortality in hospitalized patients. BMC Nephrol 20(1): 362.
8. Saour M, Zeroual N, Ridolfo J et al (2020) Serum phosphate kinetics in acute kidney injury after cardiac surgery: an observational study. J Cardiothorac Vasc Anesth 34(11): 2964-2972.
9. Fang Y, Zhang Y, Zhang X (2024) Serum phosphate levels and the development of sepsis associated acute kidney injury: Evidence from two independent databases. Front Med (Lausanne) 11: 1367064.
10. Michigami T, Yamazaki M, Razzaque MS (2022) Extracellular phosphate, inflammation and cytotoxicity. Adv Exp Med Biol 1362: 15-25.

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Published
Oct 15, 2024
DOI: https://doi.org/10.52389/ydls.v19i7.2447
Issue
Volume 19-No 7/2024
Section
Articles
How to Cite
HaiP. D., & DuongN. T. T. (2024). The value of serum phosphate level in predicting acute kidney injury in patients with septic shock. Tạp Chí Y Dược lâm sàng 108, 19(7). https://doi.org/10.52389/ydls.v19i7.2447