ISSN: 1859 - 2872
Initial outcomes of autologous bone-marrow stem cell transplantation in patients with alcoholic decompensated cirrhosis
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Abstract
Objective: To evaluate the efficacy of autologous bone marrow stem cell transplantation on liver function, histopathology, and hepatic vein pressure gradient. Subject and method: Prospective method, comparing before and after treatment alcoholic decompensated cirrhosis with autologous bone marrow stem cells. Results were evaluated according to the Child-Pugh score, MELD score, histopathological images, and hepatic vein pressure gradient. The patients were followed up at 1, 3, and 6 months after transplantation. Result: The study included 10 alcoholic decompensated cirrhosis patients with bone marrow stem cell transplantation. The CD34+ cell of bone marrow fluid collected was 0.853 x 106 cells/ml. There was a significant improvement in the clinical profile containing jaundice and ascites. No complication was observed in those patients during follow-up. Albumin level was significantly increased after transplantation in comparison with before treatment with p<0.05. After 6 months, Child-Pugh score was significantly higher than before treatment (T0) with values 5.50 ± 1.58 and 6.90 ± 2.08, respectively. There was no improvement in the MELD score, histopathological images, and hepatic vein pressure gradient. Conclusion: Liver function significantly improved in alcoholic decompensated cirrhosis patients after treatment with autologous bone marrow stem cells, and no complication was observed relating to stem cell transplantation.
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References
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