Phân tích biến cố bất lợi trong điều trị hóa chất cho bệnh nhân ung thư đại trực tràng thông qua giám sát tích cực tại Bệnh viện Trung ương Quân đội 108

Abstract

Objective: To analyze adverse events in chemotherapy for colorectal cancer patients at 108 Military Central Hospital using active surveillance. Subject and method: A cross-sectional study on 195 colorectal cancer patients undergoing chemotherapy who met the inclusion and exclusion criteria. An active surveillance method for adverse drug reactions and the Ministry of Health's guidelines for ADR prevention methods were applied to the study. Result: Of the 195 patients participating in the study, 61% were male. The median age was 61 years, and 87.2% of cancer patients were in stage IV. Regarding digestive adverse events, the rate of diarrhea and mouth ulcers were 6.1% and 9.7%, respectively. After treatment, 61.5% of patients experienced nausea, and 38.5% experienced vomiting. The majority of cases of nausea and vomiting occurred at levels 1 and 2. 95.1% of patients with an average risk level received appropriate vomiting prophylaxis. In terms of hematological events, 38.5% had leukopenia at all levels. Levels 3 and 4 constituted 13.3% of the total. 22.1% of patients recorded thrombocytopenia, predominantly at level 1. 41.1% of patients had anemia, which was also mainly at level 1. Conclusion: Active surveillance of digestive and hematological events in patients has shown more clearly the frequency and severity of events occurring in colorectal cancer patients at 108 Military Central Hospital. Some events need to be further evaluated for risk factors to have appropriate preventive measures.