ISSN: 1859 - 2872
Primary hyperparathyroidism with severe hypercalcemia due to anterior mediastinal parathyroid adenoma: A case report
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Keywords
Primary hyperparathyroidism, ectopic parathyroid adenoma
Abstract
Primary hyperparathyroidism is a relatively common endocrine disorder mainly caused by parathyroid adenoma. However, some ectopic parathyroid adenomas are sometimes challenging to diagnose. We report a case of a 64-year-old man with primary hyperparathyroidism caused by an ectopic parathyroid adenoma in the anterior mediastinum. The patient had very severe initial clinical manifestations due to hyperosmolarity caused by polyuria and hypercalcemia. Imaging tests, including parathyroid scintigraphy and CT neck and chest scans, help diagnose the tumor's ectopic state. After surgical treatment, the patient recovered completely.
Article Details
References
1. Walulik A, Misiąg W, Gajdzis P, Szymańska-Chabowska A, Chabowski M (2022) Primary Hyperparathyroidism Secondary to Ectopic Parathyroid Adenoma: A Case Report. Adv Exp Med Biol 1374: 73-79.
2. Turner JJO (2017) Hypercalcaemia - presentation and management. Clinical Medicine 17(3): 270-273.
3. Kitada M, Yasuda S, Nana T, Ishibashi K, Hayashi S, Okazaki S (2016) Surgical treatment for mediastinal parathyroid adenoma causing primary hyperparathyroidism. J Cardiothorac Surg 11:44. doi: 10.1186/s13019-016-0461-8.
4. Joliat GR, Demartines N, Portmann L, Boubaker A, Matter M (2015) Successful minimally invasive surgery for primary hyperparathyroidism: influence of preoperative imaging and intraoperative parathyroid hormone levels. Langenbecks Arch Surg 400(8): 937-944.
5. Ruda JM, Hollenbeak CS, Stack BC (2005) A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003. Otolaryngol Head Neck Surg 132(3): 359-372.
6. Krakauer M, Wieslander B, Myschetzky PS, Lundstrøm A, Bacher T, Sørensen CH, Trolle W, Nygaard B, Bennedbæk FN (2016) A Prospective Comparative Study of Parathyroid Dual-Phase Scintigraphy, Dual-Isotope Subtraction Scintigraphy, 4D-CT, and Ultrasonography in Primary Hyperparathyroidism. Clin Nucl Med 41(2): 93-100.
7. Lee SW, Shim SR, Jeong SY, Kim SJ (2021) Direct Comparison of Preoperative Imaging Modalities for Localization of Primary Hyperparathyroidism: A Systematic Review and Network Meta-analysis. JAMA Otolaryngol Head Neck Surg 147(8):692-706.
8. Wilhelm SM, Wang TS, Ruan DT et al (2016) The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism. JAMA Surg 151(10): 959-968.
9. Goldfarb S, Agus ZS (1984) Mechanism of the polyuria of hypercalcemia. Am J Nephrol 4(2): 69-76.
10. Quamme GA (1982) Effect of hypercalcemia on renal tubular handling of calcium and magnesium. Can J Physiol Pharmacol 60(10): 1275-1280.
11. Cardella CJ, Birkin BL, Rapoport A (1979) Role of dialysis in the treatment of severe hypercalcemia: report of two cases successfully treated with hemodialysis and review of the literature. Clin Nephrol 12(6): 285-290.
12. Basok AB, Rogachev B, Haviv YS, Vorobiov M (2018) Treatment of extreme hypercalcaemia: the role of haemodialysis. BMJ Case Rep 2018:bcr2017223772. doi: 10.1136/bcr-2017-223772.
13. Calò PG, Pisano G, Loi G et al (2013) Intraoperative parathyroid hormone assay during focused parathyroidectomy: The importance of 20 minutes measurement. BMC Surg 13:36.
2. Turner JJO (2017) Hypercalcaemia - presentation and management. Clinical Medicine 17(3): 270-273.
3. Kitada M, Yasuda S, Nana T, Ishibashi K, Hayashi S, Okazaki S (2016) Surgical treatment for mediastinal parathyroid adenoma causing primary hyperparathyroidism. J Cardiothorac Surg 11:44. doi: 10.1186/s13019-016-0461-8.
4. Joliat GR, Demartines N, Portmann L, Boubaker A, Matter M (2015) Successful minimally invasive surgery for primary hyperparathyroidism: influence of preoperative imaging and intraoperative parathyroid hormone levels. Langenbecks Arch Surg 400(8): 937-944.
5. Ruda JM, Hollenbeak CS, Stack BC (2005) A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003. Otolaryngol Head Neck Surg 132(3): 359-372.
6. Krakauer M, Wieslander B, Myschetzky PS, Lundstrøm A, Bacher T, Sørensen CH, Trolle W, Nygaard B, Bennedbæk FN (2016) A Prospective Comparative Study of Parathyroid Dual-Phase Scintigraphy, Dual-Isotope Subtraction Scintigraphy, 4D-CT, and Ultrasonography in Primary Hyperparathyroidism. Clin Nucl Med 41(2): 93-100.
7. Lee SW, Shim SR, Jeong SY, Kim SJ (2021) Direct Comparison of Preoperative Imaging Modalities for Localization of Primary Hyperparathyroidism: A Systematic Review and Network Meta-analysis. JAMA Otolaryngol Head Neck Surg 147(8):692-706.
8. Wilhelm SM, Wang TS, Ruan DT et al (2016) The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism. JAMA Surg 151(10): 959-968.
9. Goldfarb S, Agus ZS (1984) Mechanism of the polyuria of hypercalcemia. Am J Nephrol 4(2): 69-76.
10. Quamme GA (1982) Effect of hypercalcemia on renal tubular handling of calcium and magnesium. Can J Physiol Pharmacol 60(10): 1275-1280.
11. Cardella CJ, Birkin BL, Rapoport A (1979) Role of dialysis in the treatment of severe hypercalcemia: report of two cases successfully treated with hemodialysis and review of the literature. Clin Nephrol 12(6): 285-290.
12. Basok AB, Rogachev B, Haviv YS, Vorobiov M (2018) Treatment of extreme hypercalcaemia: the role of haemodialysis. BMJ Case Rep 2018:bcr2017223772. doi: 10.1136/bcr-2017-223772.
13. Calò PG, Pisano G, Loi G et al (2013) Intraoperative parathyroid hormone assay during focused parathyroidectomy: The importance of 20 minutes measurement. BMC Surg 13:36.
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Published
Sep 9, 2024
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How to Cite
QuỳnhL. T., ThuýN. T., NhungP. T. H., HàL. T., Hằng T. T. T., HảiN. V., Dũng Đặng T., & PhượngN. T. (2024). Primary hyperparathyroidism with severe hypercalcemia due to anterior mediastinal parathyroid adenoma: A case report. Tạp Chí Y Dược lâm sàng 108, 19(5). https://doi.org/10.52389/ydls.v19i5.2271