Mối liên quan giữa tỉ số của một số tế bào máu ngoại vi với các yếu tố tiên lượng ở bệnh nhân đa u tủy xương được điều trị tại Bệnh viện Quân y 103

Abstract

Objective: Our research aims to determine the optimal threshold for NLR (Neutrophile to lymphocyte ratio), PLR (Platelet to lymphocyte ratio), MLR (Monocyte to lymphocyte ratio) and NMLR (Neutrophile-monocyte to lymphocyte ratio) indices in prognosis and treatment response of multiple myeloma (MM). Subject and method: 57 patients newly diagnosed with MM, treated at 103 Military Hospital from April 2020 to April 2024 and 57 healthy people, who were similar in age and gender, are examined and tested at the clinic. Result: The average age was 68.77 years old, female (64.9%). Performance Status (PS) index was mainly stage 2 and 3 (accounting for 89.47%); Stage 3 accounted for 45.61%; 33 patients had GFR < 60ml/min (accounting for 57.89%); Elevated B2M concentration accounted for 59.65%, of which over 5.5 accounted for 43.86%. There were 17 patients with increased LDH concentration and 14 patients with increased blood calcium levels (proportions 29.82% and 24.56%). There was a difference between the NLR, MLR, NMLR indices of the experimental group and the control group, the PLR index had no difference. Elevated NLR > 1.72 correlated with ISS, PS; MLR > 0.23 correlated with increased B2M, blood calcium, GFR, PS and ISS; NMLR index > 2.02 correlated with ISS and PS. Conclusion: Elevated NLR, MLR, NMLR indices are useful biomarkers to predict prognosis in multiple myeloma patients.