Single nucleotide polymorphism rs2069718 in IFN-γ gene and insulin resistance in patients with type 2 diabetes mellitus

  • Bùi Khắc Cường Bệnh viện TWQĐ 108

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Keywords

rs2069718, IFN-γ, SNP, diabetes, insulin resistance

Abstract

Objective: To investigate the frequency of the single nucleotide polymorphism (SNP) rs2069718 of the IFN-γ gene and its association with insulin resistance in patients with type 2 diabetes mellitus. Subject and method: The cross-sectional descriptive study was conducted on 180 patients with type 2 diabetes mellitus. SNP genotype was determined by allele-specific PCR method. Result: In type 2 diabetes patients, rs2069718 AA genotype had the predominant proportion with 65.00%, followed by AG genotype with 29.44%, and GG genotype with 5.56% in type 2 diabetes mellitus patients. The patients with AG genotype had lower insulin concentrations than patients with GG genotype (p=0.0129) and had a lower HOMA-IR index than patients with AA genotype (p=0.0230). Conclusion: In type 2 diabetes mellitus patients, the proportion of rs2069718 AA, AG and GG genotypes in IFN-γ gene were 65.00%, 29.44% and 5.56%, respectively. The patients with AG genotype had lower insulin concentrations than patients with GG genotype and had a lower HOMA-IR index than patients with AA genotype.

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References

1. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, Pavkov ME, Ramachandaran A, Wild SH, James S, Herman WH, Zhang P, Bommer C, Kuo S, Boyko EJ and Magliano DJ (2022) IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 183:109119. doi: 10.1016/j.diabres.2021.109119.
2. Karpe F, Dickmann JR and Frayn KN (2011) Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation. J Diabetes 60: 2441-2449. doi: 10.2337/db11-0425.
3. Dali-Youcef N, Mecili M, Ricci R and Andres E (2013) Metabolic inflammation: connecting obesity and insulin resistance. Ann Med 45: 242-253. doi: 10.3109/07853890.2012.705015.
4. De George DJ, Ge T, Krishnamurthy B, Kay TWH and Thomas HE (2023) Inflammation versus regulation: how interferon-gamma contributes to type 1 diabetes pathogenesis. Front Cell Dev Biol 11: 1205590. doi: 10.3389/fcell.2023.1205590.
5. Amin K, Qadr SH, Hassan Hussein R, Ali KM and Rahman HS (2020) Levels of cytokines and GADA in type I and II diabetic patients. Prim Care Diabetes 14: 61-67. doi: 10.1016/j.pcd.2019.03.008.
6. Liu Q, Hua M, Yan S, Zhang C, Wang R, Yang X, Han F, Hou M and Ma D (2020) Immunorelated gene polymorphisms associated with acute myeloid leukemia. Clin Exp Immunol 201: 266-278. doi: 10.1111/cei.13446.
7. American Diabetes A (2019) Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care 42: 13-28. doi: 10.2337/dc19-S002.
8. Khue NT (2015) Diabetes in Vietnam. Ann Glob Health 81: 870-873. doi: 10.1016/j.aogh.2016.01.003.
9. Lam HV, Nguyen DT and Nguyen CD (2017) Sibling method increases risk assessment estimates for type 1 diabetes. PLoS One 12: 0176341. doi: 10.1371/journal.pone.0176341.
10. Toan NL, Van Hoan N, Cuong DV, Dung NV, Dung PT, Hang NT, Dieu DTH, Chung DT, Son HA, Phong PX, Lenon GB, Van De D and Van Tong H (2018) Adipose tissue-derived cytokines and their correlations with clinical characteristics in Vietnamese patients with type 2 diabetes mellitus. Diabetol Metab Syndr 10:41. doi: 10.1186/s13098-018-0343-4.

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Published
Jul 24, 2024
DOI: https://doi.org/10.52389/ydls.v19i4.2246
Issue
Volume 19 - No 4/2024
Section
Articles
How to Cite
CườngB. K. (2024). Single nucleotide polymorphism rs2069718 in IFN-γ gene and insulin resistance in patients with type 2 diabetes mellitus. Tạp Chí Y Dược lâm sàng 108, 19(4). https://doi.org/10.52389/ydls.v19i4.2246