ISSN: 1859 - 2872
Value of urinary L-FABP in predicting acute kidney injury in patients with sepsis and septic shock
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Abstract
Objective: To evaluate the value of urinary L-FABP in predicting acute kidney injury in patients with sepsis and septic shock. Subject and method: A prospective observational study was conducted in 201 patients with sepsis and septic shock at 108 Military Central Hospital. Result: Urinary L-FABP concentration in the group with AKI was 56.97 ± 12.49µg/g Cre, higher than the non-AKI group (6.37 ± 3.61µg/g Cre), p<0.05. Urinary L-FABP concentration in the Septic shock group was 43.03 ± 10.57µg/g Cre higher than the Sepsis group (28.92 ± 9.94µg/g Cre), p<0.05. Urinary L-FABP at the time the patient was admitted to the Emergency Department had predictive value for AKI occurring on the 2nd and 3rd after admission, with AUC = 0.796 and AUC = 0.732, p<0.05. Conclusion: Urinary L-FABP concentration in the group with AKI was significantly higher than the group without AKI and using urinary L-FABP at the time of admission to the Emergency Department had a predictive value for AKI appearing on the 2nd and 3rd day after admission. The estimated sensitivity of urinary L-FABP for diagnosis of AKI was 87.7% and the specificity was 87.3% at the cut point of 12.26µg/g Cre.
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