ISSN: 1859 - 2872
Assessment of mean platelet volume and mean platelet volume to platelet count ratio in anticipation of severity and mortality in sepsis
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Abstract
Objective: To evaluate whether the mean platelet volume (MPV) and mean platelet volume-to-platelet count (MPV/P) ratio are predictors of clinical severity and mortality in patients with sepsis. Subject and method: A prospective population cohort of 60 patients aged 18-97 years was recruited at the Intensive Care Unit of 108 Military Central Hospital from June 2023 to Janurary 2024 and followed up for 28 days. Patients were diagnosed with sepsis based on SEPSIS-3 septic shock criteria; in which the MPV and the MPV/P ratio were measured on days 1, 2, and 3. Sequential organ failure assessment (SOFA) score and presence of septic shock assessed clinical severity. Mortality on day 28 was considered the fatal outcome. Result: The average age of the patients was 61.2 years, male was dominant (93.3%). MPV cutoff points for mortality prediction at days 1; 2 and 3 were ≥ 9.36fL, ≥ 8.86fL and ≥ 8.76fL; and (MPV/P) ratio ≥ 8.09; ≥ 4.03; ≥3.86, respectively. MPV at days 2 (9.76fL) and 3 (8.46fL) and (MPV/ P) ratio at days 1 (4.33), 2 (4.12), and 3 (5.96), were predictors of clinical severity assessed by septic shock. Conclusion: MPV and the MPV/P ratio are predictors of clinical severity and mortality in sepsis. They should be considered as a cost-effective and rapidly available tool that guides the treatment.
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References
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