Sự tương quan giữa nồng độ HBcrAg với HBV DNA ở bệnh nhân viêm gan mạn tính và xơ gan do nhiễm HBV

Abstract

Background: Vietnam is located in an area with a high prevalence of hepatitis B virus infection. Treatment of chronic hepatitis B (CHB) is still difficult due to the prolonged existence of cccDNA in the liver, recurrence after withdrawal of NA treatment even though HBV DNA levels are undetectable. Hepatitis B core-related antigen (HBcrAg) is a biomarker found in the serum of patients that has been proven effective in monitoring and predicting treatment of chronic HBV infections. HBcrAg levels were persistently detected, even when serum HBV DNA was not detected. Studies around the world show that HBcrAg has many advantages in treatment and monitoring CHB, LC. In Vietnam, there are few studies on HBcrAg. Objective: To evaluate the correlation between HBcrAg levels and HBV DNA viral load in patients with CHB and LC. Subject and method: A cross-sectional descriptive study on 172 patients diagnosed with CHB and LC, treated at the 108 Military Central Hospital. HBcrAg levels were quantified on lumipulse G 1200 system – Fujirebio (Japan). Result: HBcrAg levels correlated linearly with the HBV DNA loads in different sub-groups, however HBcrAg levels deceased slowly than HBV DNA reduction during NA treatment. Conclusion: There is a positive correlation between HBcrAg levels and HBV DNA load. HBcrAg may be a better marker than HBV DNA in monitoring antiviral therapy in patients with chronic hepatitis B.