ISSN: 1859 - 2872
Comparing the efficacy of treating fungal finger nail infection with oral daily dose and pulse dose of terbina fineat at the National Hospital of Dermatology & Venereology
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Abstract
Objective: To compare the efficacy of treating fungal finger nail infection with oral daily dose and pulse dose of terbinafine. Subject and method: A prospective study, randomized controlled trial. There were 60 patients with fungal finger nail infection divided into two groups. Group 1 included 30 patients (18 men, 12 women) treated with oral terbinafine 250mg/day for 12 weeks. Group 2 included 30 patients (17 men, 13 women) treated with oral terbinafine 500mg/day ´ 1 week every 4 weeks for 12 weeks. Patients in both groups received oral liver tonic and topical nilocin. Patients were assessed the severity of the disease and the level of improvement in clinical symptoms at week 4, 8 and 12. Result: After 12 weeks of treatment with daily doses of terbinafine, the proportion of patients obtained subclinical clearance was 90% and clinical clearance was 66.7%. Meanwhile, this rate in the terbinafine pulse dose group was 83.3% and 56.7%, respectively, but the difference was not statistically significant. Adverse effects of terbinafine were mild and rare, which was observed in 3.3% of the daily group and 6.7% of the pulse dose group. Then main adverse effects were gastrointestinal symptoms and headaches which resolved without treatment.
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References
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