ISSN: 1859 - 2872
Study of the serum levels of cytokines IL-1α, IL-1β, IL-8, and IL-12 before and after treatment in patients with moderate and severe acne vulgaris
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Abstract
Objective: To determine the levels of cytokines IL-1α, IL-1β, IL-8, and IL-12 in the serum of moderate and severe acne vulgaris (AV) patients before and after treatment. Subject and method: A controlled clinical trial. Patient group: 90 patients with moderate and severe AV (according to Lehmann classification) and 45 healthy individuals. Cytokine quantification method using fluorescence covalent microbead immunosorbent assay at the Department of Immunology - Military Medical Academy.
Result: The serum IL-12 levels in moderate and severe AV patients were significantly higher than those in the healthy group (p<0.05). The serum levels of IL-1α, IL-1β, and IL-12 in severe AV patients were higher than in the moderate group, with statistical significance (p<0.05). The serum levels of IL-1β and IL-12 after treatment decreased with statistical significance compared to before treatment (p<0.001). Conclusion: The serum IL-12 levels in moderate and severe AV patients are higher than those in the healthy group and are related to the severity of the disease. The serum levels of IL-1β and IL-12 decrease significantly after treatment.
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References
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