ISSN: 1859 - 2872
Clinical, paraclinical characteristics and microbiological agents in exacerbation of chronic obstructive pulmonary disease with pneumonia
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Abstract
The exacerbations of chronic obstructive pulmonary disease (COPD) was the main reason leading patients to hospitalization and worsening of the disease, which can increase mortality, especially when the exacerbation with pneumonia. Objective: To study clinical, paraclinical characteristics and sputum microbiological agents in exacerbation of chronic obstructive pulmonary disease with pneumonia. Subject and method: Cross-sectional study involving 138 patients were diagnosed with exacerbation of COPD, comprising 92 patients were exacerbation of COPD with pneumonia (disease group) and 46 patients were exacerbation of COPD without pneumonia (control group). Result: The disease group was mainly male and elderly with many symptoms and risk factors. The proportion of patients with fever, respiratory failure, average CAT score, mMRC, average white blood cell count, and percentage of neutrophils in the disease group were higher than in the control group with statistical significance (p<0.05). Positive rate of agents in disease group (79.35%) was observed to be higher than in the control group (67.39%), but the difference was not statistically significant (p>0.05). The rate of single-agent or
≥ 2 agents did not show a significant difference between the two groups. Among the bacteria group Klebsiella pneumoniae was found at the highest rate in the disease group (67.12%) as well as the control group (77.41%), Haemophilus influenzae was more prevalent in the disease group (24.65%) compared to the control group (12.90%) (p>0.05). In the group of atypical bacteria, Mycoplasma pneumoniae, and Legionella pneumophila, had similar occurrences in the disease group (4.10%) and the control group (3.22%). The positive rate for influenza A/B virus was 6.84% in the disease group compared to the control group (9.67%) (p>0.05). Conclusion: The proportion of patients with fever, respiratory failure, average CAT score, mMRC, average white blood cell count, and percentage of neutrophils in the disease group were higher than in the control group with statistical significance (p<0.05). The detection rate of microbiological agents in sputum was quite high in both groups. However, there was no obvious difference between the disease group and the control group.
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References
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