ISSN: 1859 - 2872
Serum level of hs-CRP in patients with drug-induced allergic disorders at Hospital of Dermato-Venereology, Ho Chi Minh City
Main Article Content
Keywords
Abstract
Objective: To determine serum level of high-sensitivity C-reaction protein (hs-CRP) and its association with some clinical characteristics in patients with drug-induced allergic disorders. Subject and method: Serial cases report, 80 patients aged 18 years and older with drug-induced allergic disorder were enrolled from August 2015 to July 2016 at Hospital of Dermato-Venereology, Ho Chi Minh City. Diagnosis was base on history of drug intake and clinical symptoms. The classification of drug allergic reactions was based on clinical features. Determination of serum concentration of hs-CRP was performed at Medic Center. For statistical analysis we used STATA ver. 13.0 software. Result: 63.7% of the patients were males, the mean age was 33.7 ± 4.6 years, the age bracket from 20 to 39 years old was 52.5%, The majority of patients with less than or equal a high school education accounted for 71.3%. More than half of patients (56.3%) were in the provinces. Self-medication was found to be 75% for patients with drug allergic reactions, antibiotics 72.5%. Patients appeared some initial symptoms from 1 - 7 days after drug use accounted for 67.5%. Majority of clinical features were erythema multiforme 26.3% and urticaria 22.5%. Two severe clinical forms were Steven-Johnson Syndrom (SJS) 18.7% and Toxic Epidermal Necrolysis (TEN) 7.5%. The serum levels of hs-CRP (mean ± SE) were 28.92 ± 8.6mg/dl. The serum levels of hs-CRP in severe forms such as SJS, TEN were higher than other forms. This difference was statistically significant. Conclusion: The serum levels of hs-CRP have been found to be significant increased in patients with drug allergic reactions, especially in severe clinical forms such as SJS and TEN.
Keywords: Hs-CRP, drug-induced allergic disorders.
Article Details
References
2. Nguyễn Năng An, Lê Văn Khang, Nguyễn Văn Cường và cộng sự (2003) Tình hình dị ứng do thuốc ở nước ta, đề xuất những biện pháp can thiệp. Đề tài cấp Bộ Y tế.
3. Nguyễn Văn Đoàn (1996) Góp phần nghiên cứu dị ứng thuốc tại Khoa Dị ứng - Miễn dịch lâm sàng, Bệnh viện Bạch Mai. Luận án Phó tiến sĩ, Trường Đại học Y Hà Nội.
4. Phạm Công Chính (2010) Nghiên cứu tổn thương da, test phát hiện thuốc gây dị ứng và một số xét nghiệm trước, sau điều trị bệnh nhân dị ứng thuốc. Luận án Tiến sĩ y khoa, Trường Đại học Y Hà Nội.
5. Irving K, John EV, and Henry G (1982) C-Reactive protein and the plasma protein response to tissue injury. Annals of the New York Academy of Sciences, Corpus ID: 35141184.
6. Hye-In Kim, Shin-Woo Kim, Ga-Young Park (2012) Causes and treatment outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in 82 adult patients. Korean J Intern Med 27(2): 203-210.
7. Lin RY et al (2001) Interleukin 6 and C-reactive protein levels in patients with acute allergic reactions: An emergency department-based study. Ann Allergy Asthma Immunol 87(5): 412-416.
8. Linda Bertram et al (2009) Neopterin and C-reactive protein in the course of Stevens-Johnson syndrome. Acta Derm Venereol 89(3): 285-287.
Article Sidebar
