ISSN: 1859 - 2872
Serum vitamin B12 levels in patients with non-segmental vitiligo
Main Article Content
Keywords
Abstract
Objective: To investigate the difference of serum vitamin B12 levels between patients with non-segmental vitiligo compared with healthy people, and the relationships of serum vitamin B12 levels with clinical characteristics of these patients. Subject and method: A comparative cross-sectional descriptive study on patients with non-segmental vitiligo and healthy people at Ho Chi Minh city Hospital of Dermatology and Venereology. Diagnosis was based on clinical and Wood's lamp examination. Quantitative assay of serum vitamin B12 levels were measured by two-step immunoassay using chemiluminescent microparticle technology. Result: 46 patients with non-segmental vitiligo and 44 healthy people were included. The serum vitamin B12 concentration in the group of patients with non-segmental vitiligo was significantly lower than that of the control group ([553.15 (382.2-783.6) pg/mL vs. 612.55 (525-792.3) pg/mL, p<0.05]). The progressive vitiligo group had statistically significant lower serum levels of vitamin B12 than the control group [441.60 (290.50-620.00) and 612.55 (525.00-792.30) pg/mL, p<0.05], this was not observed in the stable group compared with the control group (p>0.05) and between the progressive and stable group (p>0.05). Conclusion: Serum levels of vitamin B12 in the group of patients with non-segmental vitiligo were significantly lower than that in the healthy group. There was the reduction in serum vitamin B12 levels in the group of patients with progressive non-segmental vitiligo compared with the control group. There was no decrease in serum vitamin B12 levels in the stable group compared with the control group as well as between the progressive and stable group.
Article Details
References
2. Juhlin L, Olsson MJ (1997) Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Acta dermato-venereologica 77(6): 460-462.
3. Kang S et al (2019) Fitzpatrick's Dermatology. McGraw-Hill Education.
4. Karadag AS, Tutal E, Ertugrul DT et al (2012) Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in patients with vitiligo. Clinical and Experimental Dermatology: Experimental dermatology 37(1): 62-64.
5. Park HH, Lee MH (2005) Serum Levels of Vitamin B 12 and Folate in Korean Patients with Vitiligo. Acta dermato-venereologica 85(1): 66-67.
6. Sabry HH, Sabry JH, Hashim HM (2014) Serum levels of homocysteine, vitamin B12, and folic acid in vitiligo. Egyptian Journal of Dermatology and Venerology 34(1): 65.
7. Sendrasoa FA, Ranaivo IM, Sata M et al (2019) Treatment responses in patients with Vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar. International journal of dermatology 58(8): 908-911.
8. Tjioe M, Gerritsen MJ, Juhlin L, van de Kerkhof PC (2002) Treatment of vitiligo vulgaris with narrow band UVB (311 nm) for one year and the effect of addition of folic acid and vitamin B12. Acta Derm Venereol 82: 369-372.
9. Tsai TY, Kuo CY, Huang YC (2019) Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis. Journal of the American Academy of Dermatology 80(3): 646-654.
10. Aparicio-Ugarriza R, Palacios G, Alder M, González-Gross M (2015) A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population. Clin Chem Lab Med 53(8): 1149-1159.
Article Sidebar
