ISSN: 1859 - 2872
Study on the effectiveness of oral cyclosporine in the treatment of patients with severe psoriasis vulgaris at National Hospital of Dermatology-Venereology
Main Article Content
Keywords
Severe psoriasis, cyclosporine
Abstract
Objective: To evaluate the effectiveness and safety of cyclosporine (3mg/kg/day) treatment in severe psoriasis. Subject and method: 35 severe psoriasis patients treated with cyclosporine (3mg/kg/day) for 10 weeks. Endpoint outcome was PASI 75. Result: Reduction of PASI from baseline was 78.33%. Good response 74.2%, medium response 22.86%, 2.86% had no response. Liver enzyme, serum creatinine did not raise after treatment. Some adverse events: Headache (5.71%), fatigue (11.43%), hypertension (2.86%). Conclusion: Cyclosporine A is effective treating psoriasis vulgaris.
Keywords: Severe psoriasis, cyclosporine.
Article Details
References
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7. Mahrle G, Schulze HJ, Färber L et al (1995) Low-dose short-term cyclosporine versus etretinate in psoriasis: Improvement of skin, nail, and joint involvement. Journal of the American Academy of Dermatology 32(1): 78-88.
8. Faerber L, Braeutigam M, Weidinger G et al (2001) Cyclosporine in severe psoriasis. results of a meta-analysis in 579 patients. Am J Clin Dermatol 2(1): 41-47.
2. Đặng Văn Em (2013) Bệnh vảy nến sinh bệnh học và chiến lược điều trị. Sách chuyên khảo, Nhà xuất bản Y học.
3. Amatore F, Villani AP, Tauber M et al (2019), French guidelines on the use of systemic treatments for moderate-to-severe psoriasis in adults. J Eur Acad Dermatol Venereol: 464-483.
4. Menter A, Korman NJ, Elmets CA et al (2009) Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents. Journal of the American Academy of Dermatology: 451-485.
5. Nast A, Gisondi P, Ormerod AD et al (2015) European S3‐Guidelines on the systemic treatment of psoriasis vulgaris - Update 2015 - Short version - EDF in cooperation with EADV and IPC. JEADV: 2277-2294.
6. Colombo MD, Cassano N, Bellia G et al (2013) Cyclosporine regimens in plaque psoriasis: An overview with special emphasis on dose, duration, and old and new treatment approaches. Scientific World Journal 2013:805705.
7. Mahrle G, Schulze HJ, Färber L et al (1995) Low-dose short-term cyclosporine versus etretinate in psoriasis: Improvement of skin, nail, and joint involvement. Journal of the American Academy of Dermatology 32(1): 78-88.
8. Faerber L, Braeutigam M, Weidinger G et al (2001) Cyclosporine in severe psoriasis. results of a meta-analysis in 579 patients. Am J Clin Dermatol 2(1): 41-47.
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How to Cite
ThanhL. T. H., & Em Đặng V. (2020). Study on the effectiveness of oral cyclosporine in the treatment of patients with severe psoriasis vulgaris at National Hospital of Dermatology-Venereology. Tạp Chí Y Dược lâm sàng 108, 15(3). Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/212