Nghiên cứu mối tương quan giữa mức độ nhiễm mỡ và xơ hóa gan với đặc điểm lâm sàng, cận lâm sàng bệnh gan nhiễm mỡ không do rượu ở bệnh nhân rối loạn chuyển hóa lipid máu tại Bệnh viện Quân y 175

Abstract

Objective: Survey on factors related to the degree of steatosis and liver Fibrosis in patients with lipid metabolism disorders, who had non-alcoholic fatty liver disease at 175 Military Hospital. Subject and method: Retrospective study on 201 patients with lipid metabolism disorders who examined at 175 Military Hospital from January 2019 to July 2020. A survey was conducted to investigate the factors associated with the severity of steatosis and liver fibrosis in patients with non-alcoholic fatty liver disease determined by using fibroscan. Result: The results showed that 80.6% of patients with lipid metabolism disorders had non-alcoholic fatty liver disease, with 51.85% of them having steatohepatitis. The majority (93.21%) of patients were in the mild stage of liver fibrosis, while 4.32% had significant liver fibrosis and 2.47% had advanced liver fibrosis. Patients with significant liver fibrosis were found to be older, have a higher BMI, waist circumference, and obesity, as well as elevated liver enzymes (AST, ALT, GGT) compared to those with mild liver fibrosis. However, only high GGT levels were significantly different (p=0.04). Triglycerides were identified as an independent factor predicting progressive liver fibrosis in dyslipidemia patients with non-alcoholic fatty liver disease (p = 0.01, OR = 1.32, 95% CI: 1.05-1.65). Conclusion: Patients with lipid metabolism disorder had a high prevalence of non-alcoholic fatty liver disease. The serum triglycerides concentration has been identified as an independent factor that predicts the progression of liver fibrosis in this particular group of patients.