ISSN: 1859 - 2872
Assessment of clinical, subclinical characteristics and left ventricular global longitudinal strain by 2D speckle-tracking echocardiography in patients undergoing aortic valve replacement over six-month follow-up
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Abstract
Objective: Assessment of clinical, subclinical characteristics and left ventricular global longitudinal strain by 2D speckle-tracking echocardiography in patients undergoing aortic valve replacement over six- month follow-up. Subject and method: 96 patients with severe aortic stenosis and 74 patients with severe aortic regurgitation undergoing aortic valve replacement (mean age: 60.9 ± 10.6 years; 59.4% were male). Study variables included NYHA, Sokolow Lyon index, ejection fraction (EF), left ventricular global longitudinal strain by 2D speckle-tracking echocardiography (GLS). Result: Six-month follow-up after valve replacement, the NYHA ≥ 2 decreased from 98.8% to 32%; Sokolow Lyon index decreased from 37.5 ± 2.1mm to 25.1 ± 3.8mm in the aortic stenosis group and from 41.7 ± 2.8mm to 28.8 ± 2.9mm in the aortic regurgitation group (p<0.001); EF significantly increased at six-month follow-up (aortic stenosis: 61.4 ± 11.1% to 71.8 ± 9.8%; aortic regurgitation: 58.8 ± 11.1% to 69.8 ± 9.6%; p<0,05). Preoperative GLS decreased in both aortic stenosis/aortic regurgitation groups despite preserved ejection fraction (aortic stenosis: -16.1 ± 3.5% and aortic regurgitation -14.7 ± 3.2%). Six-month follow-up after replacement, the absolute value of GLS increased (aortic stenosis group: -16.1 ± 3.5% vs -19.4 ± 1.9%; aortic regurgitation: -14.7 ± 3.2% vs -18.7 ± 1.9%). Conclusion: (1) Our results indicate that significant improvements of NYHA, Sokolow Lyon index, EF and GLS can be observed in patients undergoing aortic valve replacement. (2) GLS is a more sensitive marker for early myocardial damage than EF in patients with aortic stenosis/aortic regurgitation.
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