ISSN: 1859 - 2872
The effect of treatment on the cytokine serum levels of patients with moderate to severe acne
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Abstract
Objective: To study the effect of treatment on serum levels of IL-6, IL-8, IL-10, IL-12, and IL-17 in patients with moderate to severe acne (quantified with the GAGS score). Subject and method: A total of 80 patients with acne vulgaris 40 age- and sex-matched healthy controls were included in the study. Pre-treatment and post-treatment serum levels of IL-6, IL-8, IL-10, IL-12, and IL-17 were evaluated. Result: Serum levels of IL-6, IL-8, IL-10, IL-12, and IL-17 were significantly higher in patients with moderate to severe acne as than controls (p<0.001). However, the correlation between serum levels of IL-6, IL-8, IL-10, IL-12, and IL-17 in patients and disease severity was insignificant (p > 0.05). The mean IL-6, IL-10, and IL-17 levels underwent a statistically significant decrease after treatment (p<0.001). On the contrary, there were no significant changes in serum levels of IL-8 and IL-12 (p > 0.05). Conclusion: This study shows that isotretinoin treatment significantly decreases IL-6, IL-10, and IL-17 levels in patients with moderate to severe acne.
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