ISSN: 1859 - 2872
Clinical features, antibiotic susceptibility and treatment outcome of pediatric's Whitmore disease at Vietnam National Children’s Hospital
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Abstract
Whitmore's disease, also known as Melioidosis, is an infection in humans and animals caused by the bacterium Burkhoderia pseudomallei (B. pseudomallei). The disease can occur in all ages and regions throughout the country. Currently, in Vietnam, there are no adequate studies on the situation of Whitmore's disease in children. Objective: To describe the clinical characteristics, antibiotic sensitivity and treatment results of patient Whitmore. Subject and method: A retrospective study, describing case series, selecting all pediatric patients from 1 month to 15 years old diagnosed with Whitmore disease and treated at National Children's Hospital from 1/2016 to 01/2021. Result: 39 Whitmore children were treated at the National Children's Hospital for 5 years. In which, children ≤ 5 years old was 25 (64.1%), over 5 ≤ 10 years old was 11 (28.2%); over 10 years old was 3 (7.7%). Abscess of the angle of the jaw was the most common clinical manifestation (64.1%); followed by sepsis (20.5%); Dermatitis, meningitis, bronchitis and osteomyelitis. Specimens that were positive for B. pseudomallei were the most purulent abscesses in 24/29 patients. The sensitivity rate of bacteria to some commonly used antibiotics were ceftazidime (74%), imipenem (100%) and meropenem (100%), amoxicillin/clavulanic (65.7%), trimethoprim (54.5%). The number of patients who died was 5/39 (12.8%). Conclusion: Whitmore has a localized or generalized lesion, the most common clinical manifestation is an angle abscess, 100% is sensitive to meropennem, imipenem and only 74.2% is sensitive to ceftazidime.
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References
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