Fusobacterium nucleatum là một trong những nguy cơ có thể gây ung thư đại trực tràng

  • Nguyen Duy Truong 108 Military Central Hospital
  • Ngo Tat Trung 108 Military Central Hospital
  • Tran Thi Thanh Huyen 108 Military Central Hospital
  • Dao Thanh Quyen 108 Military Central Hospital
  • Dao Thi Huyen 108 Military Central Hospital
  • Pham Quang Trung 108 Military Central Hospital
  • Ngo Thi Hoai 108 Military Central Hospital
  • Ngo Thi Minh Hanh 108 Military Central Hospital
  • Nguyen Quang Thi 108 Military Central Hospital
  • Tran Thi Nhu Quynh Thai Binh Medical University
  • Le Huu Song 108 Military Central Hospital

Main Article Content

Keywords

Fusobacterium nucleatum

Abstract

Objective: To determine the association between F. nucleatum and colorectal cancer. Subject and method: 192 patients with polyp or colorectal cancer at different stages treated at 108 Military Central Hospital from May 2017 to December 2020 were recruited into the current cross-sectional study. The infection rate and relative load of F. nucleatum were determined in colon tissues according to stages of infection by realtime PCR. Result: The infection rate of F. nucleatum in cancer colon tissue (76.3%) was 2 times higher than that in the polyp group (37.7%); whereas F. nucleatum infection rate in malignant tissues (69.8%) was higher than that in adjacent benign tissues (46%) in stage II of cancer (p<0.05). The relative load of F. nucleatum in stage III of cancer was higher than that in stages I and II of cancer, whereas the relative load of F. nucleatum in malignant tissues was higher than that in adjacent benign tissues in stages II and III of cancer (p<0.05). Colorectal cancer group had a 3.2 times higher risk of F. nucleatum infection than benign polyp group (CI 95%: 1.2-8.8, p=0.02). Conclusion: F. nucleatum may be one of the factors associated with the development of colorectal cancer.

Article Details

References

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Published
Sep 28, 2023
DOI: https://doi.org/10.52389/ydls.v18i7.2062
Issue
Volume 18-No 7/2023
Section
Articles
How to Cite
TruongN. D., TrungN. T., HuyenT. T. T., QuyenD. T., HuyenD. T., TrungP. Q., HoaiN. T., HanhN. T. M., ThiN. Q., QuynhT. T. N., & SongL. H. (2023). Fusobacterium nucleatum là một trong những nguy cơ có thể gây ung thư đại trực tràng. Tạp Chí Y Dược lâm sàng 108, 18(7). https://doi.org/10.52389/ydls.v18i7.2062