Phân tích các vấn đề liên quan đến thuốc điều trị ung thư đại trực tràng tại Trung tâm Y học hạt nhân và Ung bướu, Bệnh viện Bạch Mai

Abstract

Objective: To determine the frequency, types of drug-related problems (DRPs) in prescribing in patients with colorectal cancer and factors affecting the occurrence of DRPs. Subject and method: A cross-sectional descriptive study on 240 colorectal cancer patients, hospitalized from February 1^st, 2023 to February 28^th, 2023. The DRPs were determined based on current recommendations and categorized using The PCNE Classification V9.1 of Pharmaceutical Care Network Europe Association. Factors affecting the occurrence of DRPs were determined by multivariable logistic regression model. Result: A total of 349 DRPs were detected from 263 cycles out of 331 treatment cycles (79.5%) with an average of 1.33 ± 0.545 DRPs/cycle with DRPs. Treatment effectiveness - P1 was the major type of DRPs (66.8%), followed by treatment safety - P2 (26.9%). Drug selection - C1 was the major cause of DRPs (57.5%), followed by dose selection - C3 (42.5%). Factors including comorbidities, type of cancer treatment regimen and number of drugs used during the treatment cycle affect the occurrence of DRPs during prescribing. Conclusion: Common drug-related problems in colorectal cancer patients with 79.5% of treatment cycles having DRPs suggest that appropriate clinical interventions by pharmacist are needed to minimize DRPs in prescribing.