ISSN: 1859 - 2872
Evaluation of medication use in patients with renal insufficiency at 108 Central Military Hospital
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Abstract
Objective: Develop a list based on consensus among medical literature and analyze prescribing practices of contraindicated medication in patients with severe renal insufficiency at 108 Military Central Hospital. Subject and method: A list of drugs that should be avoided for certain glomerular filtration rate (GFR) values was established based on consensus among various regulatory agencies. A retrospective observational study from July to December 2022 was conducted using electronic medical records of patients with severe renal insufficiency admitted to the hospital. Demographic and clinical data were collected, including patient age, sex, weight, comorbidities, medication history, and laboratory results. Prescribing practices of medication that should not be used were assessed using the developed formulary. Result: Out of over 2500 drugs of the hospital, 14 drugs were identified with estimated GFR equations. Among 143261 prescriptions in the study period, 485 (0.36%) contraindications were detected. In addition, in 95396 patients who were prescribed one or more of the medications in the list, there were approximately 0.16% (n = 151) of those had at least one contraindicated medication. Franilaxâ (Spironolactone & Furosemide) was the most prevalent prescriptions, accounting for 64.3% of patients. Conclusion: The study provides evidence for the desperate need of establishing a protocol to manage drug use in patients with severe renal impairment. The application of CDSS to prescribing software can be a promising solution to this situation.
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References
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