Đánh giá việc sử dụng kháng sinh dự phòng trong mổ lấy thai tại Khoa Sản, Bệnh viện đa khoa Thống Nhất Đồng Nai

Abstract

Objective: To investigate the characteristics of antibiotic prophylaxis and evaluate the appropriateness of drug prescribing. Subject and method: A descriptive, cross-sectional study was conducted on the medical records of 304 Cesarean section patients prescribed preoperative antibiotic prophylaxis, with discharge time during October 1, 2021 and December 31, 2021. Criteria for the critical use of antibiotic prophylaxis were based on Guidelines for using antibiotics of the Ministry of Health, 2015. Result: Among 304 patients with Cesarean section, 91.1% were given a dose of 1 g of cefazolin as a prophylactic antibiotic. Rate of surgical site infection after Cesarean section at hospital was 3.6%. The number of records with prophylactic antibiotics considered appropriate in accordance to the guidelines accounted for 80.9%. Premature or preterm rupture of membranes (OR = 2.7, CI95% = 1.4-5.2), and the anesthetic method (OR = 5.3, CI95% = 2.0-13.8) were statistically significantly associated with inappropriateness of antibiotic prophylaxis use. There were significant associations between appropriate use of prophylactic antibiotics and higher rate of wound infection at the hospital and the total treatment cost. Conclusion: Prophylactic antibiotic was prescribed appropriately in accordance to guidelines with relatively high percentage, however drug use in patients with preterm rupture of membranes and using of anesthetic method should be optimized.