ISSN: 1859 - 2872
Antibiotic resistance characteristics and factors related to treatment outcomes in patients with nosocomial infections at Vinh Phuc Hospital's intensive care unit
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Abstract
Objective: To determine antibiotic resistance rates of common bacteria causing nosocomial infections and some factors related to clinical outcomes and treatment at Department of Intensive Care, Vinh Phuc province Hospital. Subject and method: This was a prospective, cross-sectional study on 76 patients diagnosed with nosocomial infections at the Intensive Care Unit (ICU) of Vinh Phuc Province Hospital from January to September 2021. Result: The main pathogens was A. baumannii (34.4%), P. aeruginosa (18.8%) and K. pneumoniae (15.6%) with antibiotic resistanced rates with cephalosporins, quinolones, aminoglycosides, carbapenem from 50%-100% and lower resistanced to colistin group (11.1%-33%). Patients with nosocomial infections had a high mortality rate (56.6%), a high rate of septic shock (43.4%) and a long duration of treatment (18 ± 9 days). Factors associated with mortality and risk of septic shock were patients with pre-existing medical conditions, medication in the past 30 days, invasive procedures, and inappropriate empiric antibiotic therapy. Conclusion: The most common pathogens in nosocomial infections was multi-antibiotic resistant bacteria. Patients with underlying medical conditions, procedural interventions and empiric antibiotic therapy was factors related to patient outcomes.
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References
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