Đặc điểm phân bố và mức độ kháng kháng sinh của Escherichia coli gây nhiễm khuẩn niệu tại Bệnh viện Trung ương Quân đội 108 từ ngày 01/5/2022 đến ngày 30/4/2023

Abstract

Objective: To determine the infection rate and antibiotic resistance characteristics of E. coli causing urinary tract infection at the 108 Military Central Hospital from May 1, 2022, to April 30, 2023. Subject and method: All urine samples from patients suspected of urinary tract infection were cultured, identified, and subjected to antibiotic susceptibility testing. Data for identification and antibiotic susceptibility testing from urine specimens were collected in the Microbiology Department at 108 Military Central Hospital. All microbiological tests were conducted following the standard procedure recognized by ISO:15189-2012. Result: Among 6561 urine samples cultured from May 1, 2022, to April 30, 2023, there were 1029 positive cases, accounting for a rate of 15.68%. The Gram-negative bacteria infections accounted for 73.08%, Gram-positive bacteria for 20.12%, and fungal for 6.8%. The highest positive urine culture rate was observed in the Institute of Clinical Infectious Diseases (23.26%). E. coli was the most common pathogen causing urinary tract infections, accounting for 45.15% of cases in the entire hospital and 10.51% in the Intensive Care Unit. E. coli showed high sensitivity to antibiotics such as fosfomycin (96.71%), Nitrofurantoin (92.81%), carbapenems (Meropenem, Imipenem, Ertapenem) with over 90%, Amikacin (81.14%), and resistance was high against third generation Cephalosporins and Quinolone antibiotics. The rate of ESBL-producing E. coli was 60.77%. Antibiotic resistance was higher in ESBL-producing E. coli compared to non-ESBL strains, except for carbapenem antibiotics. Conclusion: The positive urine culture rate is 15.68%, with E. coli being the leading pathogen, accounting for 45.15%. E. coli demonstrated good sensitivity to antibiotics such as Fosfomycin, carbapenems, and Amikacin. ESBL-producing E. coli accounted for 60.77% and exhibited higher antibiotic resistance compared to non-beta-lactamase-producing strains, except for carbapenem antibiotics.