ISSN: 1859 - 2872
Analysis of effectiveness in the management of adverse drug-drug interactions in inpatients at National Hospital of Tropical Diseases
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Abstract
Objective: To analyze the effectiveness in the management of adverse drug-drug interactions in inpatients at the National Hospital for Tropical Diseases. Subject and method: Interventional study design with before-after comparison. In the pre-intervention period, we retrospectively carried out all electronic prescriptions and medical records of inpatients treated from 01/07/2021 to 31/12/2021. In the post-intervention period, we prospectively performed monitoring reports on the drug-drug interaction warning system and medical records of inpatients from 01/11/2022 to 30/04/2023. Result: The proportion of patients exposed to drug-drug interactions (DDIs) decreased significantly from 14.41% in the pre-intervention period to 10.09% in the post-intervention period (p<0.05). The number of prescriptions with contraindicated DDIs in the post-intervention period decreased from 95 (0.11%) to 7 (0.003%) prescriptions. The percentage of prescriptions with contraindication DDIs was 2.85% and 0.02%, respectively, in the pre-and post-intervention phases. Prescriptions rate with major DDIs decreased significantly in the post-intervention period (8.64% vs 0.78%, p<0.05). Conclusion: Clinical decision support system with drug-drug interaction warnings and clinical pharmacy activities help to reduce the frequency of DDIs. The results show that the combination of these two measures initially brings about effective DDIs management in hospital.
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References
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