Mối liên quan giữa nồng độ đáy vancomycin và kết quả điều trị viêm màng não phế cầu ở trẻ em

Abstract

Vancomycin is an antibiotic that plays an important role in the treatment of Pneumococcal meningitis in children. However, it remains still unclear whether rapidly reaching the target trough concentration of 10-15mg/L is beneficial in yielding better clinical outcomes. Objective: To evaluate the correlation between vancomycin trough concentrations and the results of treatment pneumococcal meningitis at the National Children's Hospital. Subject and method: Retrospective, cross-sectional study on 37 cases of Pneumococcal meningitis, whose were monitored the vancomycin serum level at the Center for Tropical Diseases, National Children's Hospital since July 2020 to July 2022. Result: The group that reached target trough levels at the first measurement had a shorter fever duration, a lower treatment failure rate with vancomycin, and a lower mortality/ sequelae rate than the other group. But the difference between the two groups was only statistically significant when comparing vancomycin treatment failure rates. Conclusion: Early reaching the target trough concentration improves the outcome of vancomycin treatment in children with Pneumococcal meningitis.