Correlation between characteristic imaging of lymphnode metastasis on 18F-FDG PET/CT and computed tomography in upper-third esophageal cancer patients

  • Nguyễn Đình Châu Bệnh viện Trung ương Quân đội 108
  • Bùi Quang Biểu Bệnh viện Trung ương Quân đội 108
  • Mai Hồng Sơn Bệnh viện Trung ương Quân đội 108
  • Lê Ngọc Hà Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

18F-FDG PET/CT, Upper-third esophageal cancer, lymph node metastasis, CT scan

Abstract

Objective: To evaluate the characteristic imaging of lymph node metastasis on 18F-FDG PET/CT and CT scan of upper-third esophageal cancer patients. Subject and method: A descriptive prospective study on 92 upper-third esophageal cancer patients underwent CT scan and 18F-FDG PET/CT for staging before treatment. The short axis diameter and SUVmax of lymph node were measured on CT scan and 18F-FDG PET/CT. Result: The percentage of patients diagnosed with lymph node metastasis on 18F-FDG PET/CT and CT scan were 92.4% and 63.0%. The rate of cervical, mediastinal, and abdominal lymph nodes on 18F-FDG PET/CT and CT scan were 44.0%, 54.5%, 1.5% and 47.0%, 51.2%, 1.8%, respectively. 18F-FDG PET/CT detected 277 lymph nodes while CT scan detected 117 lymph nodes. Metastatic lymph nodes on 18F-FDG PET/CT with a diameter less than 10mm accounted for 59.6% with a median SUVmax of 4.0. Conclusion: 18F-FDG PET/CT detected more lymph nodes than CT scan to avoid missing small lymph node in the staging of upper-third esophageal cancer patients.

Article Details

References

1. Rice TW, Blackstone EH, and Rusch VW (2010) 7th edition of the AJCC cancer staging manual: Esophagus and esophagogastric junction. Ann Surg Oncol 17(7): 1721-1724.
2. Ajani JA, Barthel JS, Bentrem DJ et al (2011) Esophageal and esophagogastric junction cancers. J Natl Compr Canc Netw 9(8): 830–887.
3. Elsherif SB, Andreou S, Virarkar M et al (2020) Role of precision imaging in esophageal cancer. J Thorac Dis 12(9): 5159-5176.
4. Jiang C, Chen Y, Zhu Y et al (2018) Systematic review and meta-analysis of the accuracy of 18F-FDG PET/CT for detection of regional lymph node metastasis in esophageal squamous cell carcinoma. J Thorac Dis 10(11): 6066-6076.
5. Bộ Y tế (2013) Quyết định về việc ban hành tài liệu Hướng dẫn quy trình kỹ thuật Chẩn đoán hình ảnh và điện quang can thiệp. Số 25 /QĐ-BYT ngày 3-1-2013.
6. Boellaard R, Delgado-Bolton R, Oyen WJG et al (2015) FDG PET/CT: EANM procedure guidelines for tumour imaging: Version 2.0. Eur J Nucl Med Mol Imaging 42(2): 328-354.
7. Wakita A, Motoyama S, Sato Y et al (2020) Evaluation of metastatic lymph nodes in cN0 thoracic esophageal cancer patients with inconsistent pathological lymph node diagnosis. World J Surg Oncol 18(1): 111.
8. Wahl RL, Jacene H, Kasamon Y et al (2009) From RECIST to PERCIST: Evolving considerations for pet response criteria in solid tumors. J Nucl Med 50(1): 122-150.
9. Garcia B, Goodman KA, Cambridge L et al (2016) Distribution of FDG-avid nodes in esophageal cancer: Implications for radiotherapy target delineation. Radiat Oncol 11(1): 156.
10. Ding X, Zhang J, Li B et al (2012) A meta-analysis of lymph node metastasis rate for patients with thoracic oesophageal cancer and its implication in delineation of clinical target volume for radiation therapy. Br J Radiol 85(1019): 1110-1119.
11. Mai Xuân Long, Trần Việt Tú và Nguyễn Kim Lưu (2016) Nghiên cứu đặc điểm lâm sàng, cận lâm sàng, hình ảnh PET/CT của bệnh nhân ung thư thực quản. Y Dược học Quân sự 41(9), tr. 141-146.