Mối liên quan giữa hình ảnh PET/CT với đột biến gen KRAS, NRAS, BRAF trong ung thư đại trực tràng

Abstract

Objective: To evaluate the association between SUV, MTV, TLG with KRAS, NRAS and BRAF gene mutations in colorectal cancer. Subject and method: A descriptive, retrospective, and prospective study on 115 colorectal cancer patients who were taken with ¹⁸FDG-PET/CT before treatment. Result: The indexes SUVmax at primary tumor, T/NT, T-NT in the group with at least 1 KRAS/NRAS/BRAF gene mutation were higher than in the group without the mutation, (p=0.001, 0.003 and 0.001, respectively). With a threshold value of 9.5 SUVmax could predict KRAS/NRAS/BRAF mutation status with sensitivity of 87.50% and specificity of 41.18%; with a threshold value of 4.72, the T/NT index could predict KRAS/NRAS/BRAF mutation status with a sensitivity of 53.13% and a specificity of 72.55%; with a cutoff value of 6.82 T-NT could predict KRAS/NRAS/BRAF mutation status with a sensitivity of 85.94% and a specificity of 41.18%. SUVmax value at primary tumor in the group with KRAS gene mutation was higher than that in the group without KRAS gene mutation, the difference was statistically significant with p=0.031; The area under the ROC curve was 0.662. With a threshold value of 13.96 SUVmax could predict KRAS mutation status with a sensitivity of 67.35% and a specificity of 61.54%. Conclusion: There is a relationship between SUVmax at primary tumor, T/NT, T-NT and KRAS/NRAS/BRAF gene mutations. There is a relationship between SUVmax at primary tumor and KRAS gene mutation.