ISSN: 1859 - 2872
Treatment results of intensity modulated radiation therapy in radioactive iodine-refractory diffrentiated thyroid cancer patients with locoregional recurrence/metastasis
Main Article Content
Keywords
Abstract
Objective: To assess the outcomes of intensity modulated radiation therapy (IMRT) in radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC) patients with locoregional recurrence/metastasis. Subject and method: A retrospective study was conducted on 32 patients with RAI-R DTC who underwent intensity-modulated radiation therapy (IMRT) for locoregional recurrence/ metastasis at the 108 Military Central Hospital. Locoregional control (LRC) and overall survival (OS) were estimated by using the Kaplan-Meier curve. Acute and late toxicities of radiotherapy were assessed based on RTOG toxicity criteria. Result: With a median follow-up time of 45.8 months, the estimated LRC and OS rates at 1, 3, 5 year were 93.4%, 82.8%, 82.8% and 96.8%, 82%, 82%, respectively. The most common acute toxicities of radiotherapy were grade I-II xerostomia, mucositis, while the most frequent late toxicities were grade I xerostomia and dermatitis. Conclusion: Intensity-modulated radiation therapy showed promising local control rate and long term overall survival in radioactive iodine-refractory differentiated thyroid cancer patients with acceptable toxicities.
Article Details
References
2. Haugen BR, Alexander EK, Bible KC et al (2016) 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 261: 1-133.
3. Durante C, Haddy N, Baudin E et al (2006) Long-Term Outcome of 444 Patients with Distant Metastases from Papillary and Follicular Thyroid Carcinoma: Benefits and Limits of Radioiodine Therapy. The Journal of Clinical Endocrinology & Metabolism 918: 2892-2899.
4. Fontenot TE, Deniwar A, Bhatia P et al (2015) Percutaneous ethanol injection vs reoperation for locally recurrent papillary thyroid cancer: A systematic review and pooled analysis. JAMA Otolaryngol Head Neck Surg 1416: 512-518.
5. Brierley J, Tsang R, Panzarella T et al (2005) Prognostic factors and the effect of treatment with radioactive iodine and external beam radiation on patients with differentiated thyroid cancer seen at a single institution over 40 years. Clin Endocrinol (Oxf) 634: 418-427.
6. Kim TH, Yang DS, Jung KY et al (2003) Value of external irradiation for locally advanced papillary thyroid cancer. Int J Radiat Oncol Biol Phys 554: 1006-1012.
7. Kim Young Suk, Choi Jae Hyuck, Kim Kwang Sikand et al (2017) The role of adjuvant external beam radiation therapy for papillary thyroid carcinoma invading the trachea. Radiat Oncol J 352: 112-120.
8. Lee EK, Lee YJ, Jung YS et al (2015) Postoperative simultaneous integrated boost-intensity modulated radiation therapy for patients with locoregionally advanced papillary thyroid carcinoma: preliminary results of a phase II trial and propensity score analysis. J Clin Endocrinol Metab 1003: 1009-1017.
9. Chow SM, Yau S, Kwan CK, Poon PC, Law SC (2006) Local and regional control in patients with papillary thyroid carcinoma: specific indications of external radiotherapy and radioactive iodine according to T and N categories in AJCC 6th edition. Endocrine-Related Cancer Endocr Relat Cancer 134: 1159-1172.
10. Beckham TH, Romesser PB, Groen AH et al (2018) Intensity-Modulated Radiation Therapy With or Without Concurrent Chemotherapy in Nonanaplastic Thyroid Cancer with Unresectable or Gross Residual Disease. Thyroid 289: 1180-1189.
11. Groen AH, van Dijk D, Sluiter W et al (2022) Postoperative external beam radiotherapy for locoregional control in iodine refractory differentiated thyroid cancer. Eur Thyroid J 111.
12. Cox JD, Stetz J, Pajak TF (1995) Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 315: 1341-1346.
Article Sidebar
