ISSN: 1859 - 2872
The results of preoperative short-course radiation therapy combine laparoscopic total mesorectal excision for rectal cancer
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Abstract
Objective: To evaluate the results of preoperative short-course radiation therapy combined with laparoscopic total mesorectal excision for rectal cancer. Subject and method: 70 patients stage II, III, mid and low rectal cancer were treated with short-course radiation therapy combined with laparoscopic total mesorectal excision at 108 Military Central Hospital. The patient’s data were recorded: Patient’s characteristics, short-term and the 5-year results. Result: The mean patients age was 59.6 years (34-80). The mean BMI was 20.5 (14.7-28.0). Male/female ratio was 44/26. Mid rectal cancer was 50.0% and low rectal cancer was 50.0%. Preoperative on MRI stage II, III were 12.9% and 87.1%, respectively. Low anterior resection was 74.3% and abdominoperineal resection was 25.7%. Complete and nearly complete mesorectum were 63.6% and 36.4%, respectively. Negative distal margin rate was 98.0%. Negative circumferential resection margin rate was 98.5%. Pathological stage I, II and III rates were 14.3%, 64.3% and 21.4%, respectively. There were 58 patients followed up at 5 years with results: Overall survival was 84.5% and disease-free survival was 81.0%. The 5-year cumulative local recurrence rate was 12.1%. Late toxicity grade 3-4 was 12.1%. Second cancers rate was 5.2%. Conclusion: Laparoscopic total mesorectal excision for mid and low rectal cancer with preoperative short-course radiation therapy is safety, effective. 5 years overall survival rate was 84.5% and disease-free survival was 81.0%. The 5-year cumulative local recurrence rate was 12.1%. Second cancers rate was 5.2%.
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